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Node study: 'Esophageal resection for patients with esophageal cancer and cervical lymph node metastases'

To assess the safety and feasibility of curative esophagectomy combined with three field lymphadenectomy after chemo-radiation in Western patients with resectable thoracic esophageal carcinoma and cervical lymph node metastases in level III and/ or…

Nutritional Route In Esophageal Resection trial

This study aims to determine whether early start of oral intake in patients that underwent an esophagectomy is feasible and safe.

Irreversible electroporation treatment in patients with pancreatic locally advanced adenocarcinoma

The objective of this study is to investigate the amount of clinically relevant complications (defined by Clavien-Dindo score 3 or higher) caused by IRE in patients with locally advanced, non-resectable, non-metastasized, pancreatic cancer.

CHEMORADIOTHERAPY FOR RECTAL CANCER IN THE DISTAL RECTUM FOLLOWED BY ORGAN-SPARING TRANSANAL ENDOSCOPIC MICROSURGERY
CARTS study
CApecitabine, Radiotherapy and Tem Surgery. A PHASE II, FEASIBILITY TRIAL

Objective of this research is to evaluate whether neo-adjuvant chemo-/radiotherapy in small non-advanced rectal cancers can be used to obtain a complete or near complete remission. In these patients could a complete resection of the rectum as an…

transanal total rectal excision a hybrid notes procedure
the introduction of a new technique

The objective of this new approach is: to reduce the number of conversionsfaster recoveryshorter hospital stay

A Multicenter Phase II Study of Neoadjuvant Docetaxel, Cisplatin and Capecitabine and Protocolized Surgery in Resectable Gastric Cancer
An IKZ-based phase II feasibility study

This study investigates the feasibility role of neoadjuvant chemotherapy, consisting of docetaxel (Taxotere), cisplatin and capecitabine (Xeloda) (TCX), and protocolized surgery in localized and/or locally advanced resectable gastric cancer (D1extra…

Radioembolization for Colorectal Liver Metastases after Ablation: a Prospective study

Primary objective is to assess the efficacy of ablation therapy in combination with Y-90 radioembolization in patients with CRLM. Secondary objectives are: 1) Assessment of occurrence of any treatment related adverse events following ablation in…

Neo-adjuvant FOLFOXIRI and chemoradiotherapy for high risk (*ugly*) locally advanced rectal cancer.

This study has been transitioned to CTIS with ID 2023-509758-74-00 check the CTIS register for the current data. The aim of this study is to assess the effectiveness of the addition of neoadjuvant induction FOLFOXIRI systemic therapy to…

Endoscopic sutured gastroplasty with endomina in diabetic, obese patients * prospective interventional study

The primary objective of this study is to evaluate the efficacy of endoscopic sutured gastroplasty (ESG) with the endomina device (EndoTools Therapeutics S.A.) in combination with optimal lifestyle measures on glycemic control, in obese patients…

Safety and feasibility of CT-guided percutaneous radionuclide therapy with the OncoSil* device in patients with non-progressive locally advanced pancreatic cancer (PANCOSIL): an open-label, single-arm phase 1-2 feasibility study

To assess the safety and feasibility of percutaneous CT-or ultrasound-guided RNT using the Oncosil* device in patients with non-progressive LAPC after induction chemotherapy treatment.

Assessing optimal treatment settings for the ablation of locally advanced pancreatic cancer with CT-guided percutaneous irreversible electroporation: a randomized feasibility study.

The objective of this study is to compare two IRE protocols for the treatment of LAPC that are currently being used in clinical treatment, to allow for the determination (based on survival and co-morbidity) of the optimal treatment protocol for IRE…

Organ preservation in patients with a good clinical response after neoadjuvant (chemo)radiation for rectal cancer: optimization of treatment strategies and defining the role of additional contact x-ray brachytherapy versus extending the waiting interval and local excision.

The aim of this study is to investigate which rate of organ preservation can be achieved in patients with rectal cancer treated with neoadjuvant (chemo)radiotherapy with a good clinical response, and to optimize the different treatment strategies (…

Feasibility of a subcutaneous gluteal transposition flap without donor site scar for perineal closure after extralevator abdominoperineal resection for rectal cancer

The aim of this study is to determine feasibility of perineal reconstruction using a gluteal subcutaneous transposition flap (Luna flap) after eAPR for rectal cancer.

Cytoreductive surgery and Intraperitoneal chemotherapy and for Stomach CAncer: a feasibility study

To assess the safety and feasibility of HIPEC and CS in Western patients with peritoneal metastases of gastric cancer, in terms of morbidity and mortality. Secondary objective is to determine the effect on survival and recurrence.

Adaptive anastomosis for anterior resection in sigmoid and proximal rectal cancer or premalignant lesions: a multicentre non-randomised clinical effectiveness trial (ADAPT)

The aim of this trial is to investigate the safety and efficacy of an adaptive anastomosis using the C-REX RectoAid Cath following elective anterior resection for sigmoid or proximal rectal cancer, or premalignant lesions not amenable tot endoscopic…