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PILOT STUDY PROTOCOL: LOW-PRESSURE PNEUMOPERITONEUM WITH DEEP NEUROMUSCULAR BLOCKADE IN BARIATRIC SURGERY TO REDUCE POSTOPERATIVE PAIN

Aim of this pilot study is to determine which intervention groups are feasible in a larger trial which aims to a compare postoperative pain and complication rates in moderate versus deep neuromuscular blockade, and normal versus low intra-abdominal…

Concomitant intraperitoneal and systemic chemotherapy in patients with extensive peritoneal carcinomatosis of colorectal origin

Main objective of this project is to establish the maximum tolerable dose (MTD) and recommended phase II dose of intraperitoneal irinotecan in patients with PC of colorectal origin, added to standard of care systemic chemotherapy. Other endpoints…

Improving compliance to the ERAS care pathway through improving patient participation by using eHealth

The aim is to improve compliance to the ERAS protocol. Therefore an application for smartphone will be developed to be used by the patient undergoing colorectal surgery. Objective of this study is to generate evidence that a mobile app can activate…

Influence of body weight on brain structure and function, the BARICO study, BAriatric surgery Rijnstate and RadboudUMC neuroImaging and Cognition in Obesity

To determine the effect of weight loss after bariatric surgery (BS) on different measures of cognition, brain function and structure investigated with various neuropsychological tests and studying various magnetic resonance imaging (MRI) parameters…

Laparoscopic Roux-en-Y Gastric Bypass and Laparoscopic Sleeve Gastrectomy for Severe Obesity in Teenagers: a prospective cohort study.

To implement and assess the feasibility, efficacy and safety of bariatric surgery in adolescents with severe obesity together with a multidisciplinary care pathway around the procedure.

Assessing optimal treatment settings for the ablation of locally advanced pancreatic cancer with CT-guided percutaneous irreversible electroporation: a randomized feasibility study.

The objective of this study is to compare two IRE protocols for the treatment of LAPC that are currently being used in clinical treatment, to allow for the determination (based on survival and co-morbidity) of the optimal treatment protocol for IRE…

Intraoperative Fluorescence Angiography to Prevent Anastomotic Leak
in Rectal Cancer Surgery

The aim of this research is to investigate the efficacy and mechanism of anew technology, intra-operative fluorescence angiography (IFA), inreducing anastomotic leak rate following elective rectal cancer surgery.The comparator will be standard white…

Improving the preoperative status of patients undergoing major surgery

To evaluate the feasibility of (1) the use of the Beter Voorbereid* application and the study procedures of a randomized controlled trial (finished in June 2019) and (2) evaluating the effectiveness of the *Beter Voorbereid* application on improved…

Mesenteric Sparing versus more extended mesenterectomy in Ileocolic Resection for ileocecal Crohn*s Disease

With this study, we hope to decrease recurrent Crohn*s disease.

Multicentre, randomised controlled trial comparing TRansanal minimal InvAsive Surgery (TAMIS) and endoscopic Submucosal dIsseCtion (ESD) for resection of non-pedunculated rectal lesions.

The aim of this study is to compare both procedures with regard to recurrence rates and complete (R0) resection rate, and to put this into perspective against the costs and complication rates of both strategies and the burden perceived by patients…

Intraoperative Music to PROMote PaTient oUtcome (IMPROMPTU): a double-blind, placebo-controlled, randomized multicenter trial

The main objective of this study is to investigate whether intraoperative music reduces postoperative pain in patients undergoing surgery for esophageal or stomach cancer. Secondary objectives are the effects of intraoperative music on…

External beam radiation therapy versus stent insertion for dysphagia relief in esophageal cancer: a multi-center randomized trial

Primary objectiveThe primary objective of this study is to compare the efficacy of EBRT versus SEMS insertion for palliation of malignant dysphagia in esophageal cancer patients at 4 weeks after start of treatment.Secondary objectivesSecondary…

RECOVER study: the effect of low- versus normal pressure pneumoperitoneum during laparoscopic colorectal surgery on the early quality of recovery with perioperative care according to the enhanced recovery principles.
Substudy: the effectiveness of low pressure pneumoperitoneum during laparoscopic colorectal surgery in preserving innate immune homeostasis by reducing peritoneal mesothelial cell injury.

Main study: to establish the relationship between the use of low pressure pneumoperitoneum with deep neuromuscular blockade and the early quality of recovery after laparoscopic colorectal surgery with perioperative care according to the enhanced…

AXIOMA: Hot AXIOS metal stent for infected walled-off pancreatic necrosis management.

Investigate whether the use of the Hot AXIOS lumen apposing metal stent is superior to standard plastic pigtails stents for drainage of infected pancreatic necrosis.

Designing for co-responsibility to improve patient engagement, a data-enabled approach

The purpose of this research is to explore the needs of obesity patients and their partners or loved ones, to permanently change their lifestyle. These knowledge and insights can be used for new developments or to improve existing products/…

Distal pancreatectomy, minimally invasive or open, for malignancy (DIPLOMA)

To compare MIDP with ODP regarding radical resection rate) for pancreatic ductal adenocarcinoma (PDAC) in the pancreatic body or tail.

Clinical pharmacoloGy of platinUm-based hyperThermic intraperitoneal chemotherapy: exploration of the impact of flushing on tumOur, systemic and personnel eXposure

Primary objective:1. To explore the effect of flushing after HIPEC on tissue platinum exposureSecondary objectives:1. To explore the effect of flushing after HIPEC on wound exudate platinum concentration2. To explore the effect of flushing after…

Ligation of the gastrosplenic ligament during upper gastrointestinal surgery; Effect on splenic and gastric perfusion: pilot study

This pilot study aims to report on the diagnostic value of indocyanine green and fluorescence laparoscopy on vascularization defects of the stomach and spleen during antireflux surgery.It is our hypothesis that many splenic and gastric infarctions…

Mobile Vital Sign tracking in high risk surgical ward patients

Primary objective:1. To investigate to what extent continuous vital sign monitoring can improve detection of adverse events in surgical ward patients as compared to current MEWS and nurse-worry assessmentSecondary objectives:2. To explore the…