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Taking control of prehabilitation in older patients with colorectal carcinoma

Investigate whether continuous monitoring of physical activity with an activity tracker leads to an improvement in preoperative endurance in elderly people with colorectal cancer, compared to a standard preoperative route with prehabilitation.

Laser speckle contrast imaging, surgical eye and indocyanine green fluorescence imaging for perfusion assessment of the gastric conduit

In this trial we will study the utility of PerfusiX-Imaging for perfusion assessment of the gastric conduit in comparison with the standard of care.

Creating a laparoscopIc banded sleeve gastrectomy

To investigate the effect of banded sleeve gastrectomy

SpHincterotomy for Acute Recurrent Pancreatitis

The hypothesis is that obstruction at the level of the minor papilla is one cause of RAP in pancreas divisum; miES will relieve the obstruction, thereby reducing the risk of a recurrent attack(s) of acute pancreatitis.

A step-up approach: CRP first followed by CT-scan imaging to
ensure Quality Control after Major Abdominal Surgery. the
PRECious trial

Aim of the PRECious trial is to evaluate the effect of a standardized postoperative algorithm for quality control (via standardized measurement of CRP levels and CT-scan imaging) on morbidity and mortality after major digestive surgery.

Tailoring Limb length based on total small bowel length in omega-loop gastric bypass

To investigate whether adjusting the length of the BP-limb of the OAGB based on measured total small bowel length leads to more weight loss, resolution of co-morbidities with less development of micronutrient deficiencies and bowel movements…

SURGERY FOR ADENOCARCINOMA OF THE GASTROESOPHAGEAL JUNCTION (GEJ) TYPE II: TRANSTHORACIC ESOPHAGECTOMY VS. TRANSHIATAL EXTENDED GASTRECTOMY (CARDIA trial)

The aim of the study is to compare transthoracic esophagectomy versus transhiatal extended gastrectomy in patients with GEJ type II tumors. It is hypothesized that esophagectomy allows for a higher rate of radical resections and a more complete…

A multimodal prehabilitation and rehabilitation program for frail older colorectal cancer patients

The aim is to investigate the effect of a multimodal prehabilitation and rehabilitation program in frail patients of 70 years or older, undergoing elective surgery for non-metastatic CRC on1. One-year mortality 2. Postoperative complications,…

Neo-adjuvant FOLFOXIRI and chemoradiotherapy for high risk (*ugly*) locally advanced rectal cancer.

This study has been transitioned to CTIS with ID 2023-509758-74-00 check the CTIS register for the current data. The aim of this study is to assess the effectiveness of the addition of neoadjuvant induction FOLFOXIRI systemic therapy to…

Effect of preoperative weight loss with a 14-day low-calorie diet on surgical procedure and outcomes in patients undergoing RYGB surgery.

The primary objective is to evaluate the effect of preoperative weight loss (by means of a 14-day low-calorie diet) on the operative time of the RYGB procedure. The first secondary objective is to evaluate the effect of preoperative weight loss on…

Lanorec study: Lateral Nodal Recurrence in rectal Cancer

To investigate whether a standardized multidisciplinary treatment of rectal cancer patients with enlarged lateral lymph nodes will decrease the amount of local recurrences. Secondary outcomes are morbidity, quality of life and functional outcomes.

*Evaluating the feasibility of intraluminal oxygen administration at the site of the anastomosis in patients who underwent an esophagectomy; a pilot study*

To explore feasibility of intraluminal oxygen administration at the site of the anastomosis in patients who underwent an esophagectomy.

Treatment of Hemorrhoids: Rubber band ligation Or Sclerotherapy

We want to compare the effectiveness of sclerotherapy and rubberband ligation when it comes to symptoms. We will secondarily consider patient satisfaction, complications and recurrences. We hypothesize that both treatments are equally effective.

A Prospective, Post-Market, Multicenter, Randomized Controlled Trial to Compare the Performance of the EndoRotor® System Versus Conventional Endoscopic Techniques for Direct Endoscopic Necrosectomy of Walled Off Necrosis

To assess the performance of the EndoRotor, as compared to conventional endoscopic techniques, for direct endoscopic necrosectomy (DEN) of walled off necrosis (WON)

Stoma APPtimize: Improving quality of life of patients having a stoma by offering personalised and timed guidance and peer-contact in a patient-centred mobile application

The main objective of this study is to investigate whether quality of life can be improved by personalised and timed guidance, and/or use of the peer-support platform; as provided by a patient-centred mobile application.

Peri-operative (Continuous) Remote Patient Monitoring of Patients Undergoing Major Gastrointestinal Surgery: a Feasibility Study

The aim of this study is to determine the feasibility of perioperative (continuous) remote patient monitoring using Ehealth devices and a daily questionnaire in patients undergoing major gastrointestinal surgery. Additionally, to determine (early)…

Endoscopic sutured gastroplasty with endomina in diabetic, obese patients * prospective interventional study

The primary objective of this study is to evaluate the efficacy of endoscopic sutured gastroplasty (ESG) with the endomina device (EndoTools Therapeutics S.A.) in combination with optimal lifestyle measures on glycemic control, in obese patients…

Pilot study to determine the intraTUMORal OsImertinib concentration in patients with peritoneal metastasizeD colorectal cancer (TUMOROID study)

The main objective of this pilot study is to determine the intratumoral concentrations of osimertinib upon 1 week of treatment in peritoneal metastasis of patients who are candidate for CRS-HIPEC treatment (group 1) and in liver metastasis of…

The influence of having bariatric surgery on the pharmacokinetics, safety and efficacy of the novel non-nucleoside reverse transcriptase inhibitor doravirine (LABRADOR)

Primary objective: • To assess the pharmacokinetics of DOR in patients prior to and after BSSecondary objectives: • To assess the safety of DOR in patients prior to and after undergoing BS• To assess the viral response to DOR in patients prior to…

Improving compliance to the ERAS care pathway through improving patient participation by using eHealth

The aim is to improve compliance to the ERAS protocol. Therefore an application for smartphone will be developed to be used by the patient undergoing colorectal surgery. Objective of this study is to generate evidence that a mobile app can activate…