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FiberUP in clinical practice

To investigate the feasibility of increasing preoperative dietary fiber intake in CRC patients undergoing surgery via 1) personalized dietary advice (Vezel-UP tool), or 2) vegetable product containing natural fibers (WholeFiber) compared to 3)…

Treatment of PERitoneal dissemination in Stomach Cancer patients with
cytOreductive surgery and hyperthermic intraPEritoneal chemotherapy: the
PERISCOPE II study

This study has been transitioned to CTIS with ID 2023-510159-53-01 check the CTIS register for the current data. The primary aim of this study is to compare the overall survival between gastric cancer patients with limited peritoneal carcinomatosis…

Peroperative Administration of Tranexamic acid in Roux-en-Y and one-anastomosis gastric bypass to reduce hemorrhage rates (PATRY study): a randomized controlled trial

This study has been transitioned to CTIS with ID 2024-513570-22-00 check the CTIS register for the current data. This trial aims to investigate whether peroperative administration of TXA reduces haemorrhage rates in patients who undergo metabolic…

Randomized Controlled Trial of Laparoscopic Primary Diaphragm Repair with Sutures Alone versus Sutures Reinforced with Mesh for Hiatus Hernia: A Long-Term Follow-Up

To assess the recurrence of hiatal hernia five to ten years after repair using sutures versus sutures reinforced with non-absorbable mesh.

Cardiac and intramuscular adaptations following short-term exercise prehabilitation in unfit patients scheduled to undergo hepatic or pancreatic surgery

The main objective is to assess the central (cardiac function) and peripheral (skeletal muscle function) physiological adaptations in response to exercise prehabilitation.

Improving the preoperative status of patients undergoing major surgery

To evaluate the feasibility of (1) the use of the Beter Voorbereid* application and the study procedures of a randomized controlled trial (finished in June 2019) and (2) evaluating the effectiveness of the *Beter Voorbereid* application on improved…

*Improving clinical management of colon cancer through CONNECTION, a nation-wide Colon Cancer Registry and Stratification effort.*

Primary objective:Evaluation of the pathological tumour response to neoadjuvant systemic chemotherapy per CMS subtype in patients with microsatellite stable high risk stage II and stage III colon cancer.Secondary Objectives: • Evaluation of the…

Mesenteric Sparing versus more extended mesenterectomy in Ileocolic Resection for ileocecal Crohn*s Disease

With this study, we hope to decrease recurrent Crohn*s disease.

Multicentre, randomised controlled trial comparing TRansanal minimal InvAsive Surgery (TAMIS) and endoscopic Submucosal dIsseCtion (ESD) for resection of non-pedunculated rectal lesions.

The aim of this study is to compare both procedures with regard to recurrence rates and complete (R0) resection rate, and to put this into perspective against the costs and complication rates of both strategies and the burden perceived by patients…

Implementation of optimized and standardized surgical technique for right-sided colon cancer: a prospective interventional sequential cohort study with a transition period

The main objective of this study is to improve surgical and oncological outcomes for patients with right-sided colon cancer by conducting a prospective sequential interventional cohort study that aims to evaluate national implementation of the LRHC…

The GATE trial: Endoscopic sutured Gastroplasty in Type 2 diabetic, obese patients using the Endomina device - a randomized controlled trial, and its effect on incretin hormones

The primary objective of this study is to evaluate the efficacy of endoscopic sutured gastroplasty with the endomina device (EndoTools Therapeutics S.A.) on glycemic control (reduction in insulin dose), in obese insulin treated type 2 diabetes…

SGM-101 tumor-targeted fluorescence endoscopy to enable discrimination of malignant from benign tissue in rectal polyps with suspected T1 adenocarcinoma or high grade dysplasia: a feasibility study

This study has been transitioned to CTIS with ID 2024-510769-41-00 check the CTIS register for the current data. The main objective is to investigate the feasibility of a tumour-targeted fluorescent tracer SGM-101, combined with the use of the CE-…

Recurrences after standard EMR vs plus thermal ablation EMR of advanced sessile and lateral spreading colorectal adenoma: a multicenter, randomized controlled trial

Does STSC decreases the recurrence rate after EMR in patients with large lateral spreading or sessile polyps?

Biological OviTex versus synthetic graft in robotic prolapse surgery: a multicentre, phase II-III, partially randomized patient preference trial

Main study parameter/endpoint phase II- Post-operative morbidity measured by reoperations, reinterventions, re-admissions, serious adverse events, Clavien Dindo classification and CTS classification. - The rate of rectal prolapse recurrence and…

Multicentre, open-label, randomised, controlled, parallel arms clinical trial of induction chemotherapy followed by chemoradiotherapy versus chemoradiotherapy alone as neoadjuvant treatment for locally recurrent rectal cancer - PelvEx II study

This study has been transitioned to CTIS with ID 2024-512526-28-00 check the CTIS register for the current data. The primary objective of this study is to determine whether the addition of induction chemotherapy to the neoadjuvant treatment of…

A study on safety and efficacy comparing 150cm One Anastomosis Gastric Bypass with 150cm BP limb Roux-en-Y Gastric Bypass (Roux-en-WHY?): An open label, multicentre non-inferiority randomized controlled trial

The objective of this study is to find out whether a 150cm BPL-length OAGB is just as good in treating morbidly obese adults when compared to a 150cm BPL-length RYGB with a 75cm Roux-limb in terms of percentage excess BMI loss and nutritional…

Towards Response guided ADAptive Radiotherapy for organ preserving treatment of intermediate risk rectal cancer: a phase I dose finding trial

The main objective is to determine the maximum tolerated dose (MTD) that will be the recommended radiation dose for the phase 2 study, in which we intend on using a MR-guided boost after SCRT in patients with intermediate risk rectal cancer to…

The banded mini gastric bypass trial

The main objective is the %TBWL 5 years after surgery. Secondary objectives include Percentage Excess Weight Loss (%EWL); decrease of comorbidities such as diabetes mellitus (DM), hypertension, and hypercholesterolemia; improvement of quality of…

Concomitant intraperitoneal and systemic chemotherapy in patients with extensive peritoneal carcinomatosis of gastric origin

This study has been transitioned to CTIS with ID 2024-516265-37-00 check the CTIS register for the current data. The primary goal of the study is to establish the maximum tolerated dose (MTD) of intraperitoneal administration of irinotecan, added to…

Robot-assisted minimally invasive thoraco-laparoscopic esophagectomy versus minimally invasive esophagectomy for resectable esophageal cancer, a randomized controlled trial (ROBOT-2 trial).

The objective is to evaluate the extent of lymph node dissection, efficacy, risks, quality of life and cost-effectiveness of RAMIE as an alternative to MIE as treatment for esophageal cancer.