62 results
To assess the feasibility and safety of intraoperative dual-modality imaging in patients with renal cell carcinoma with Indium-111-DOTA-girentuximab-IRDye800CW. Secondary objectives are to assess how intraoperative fluorescence imaging results…
- To evaluate the bladder-preservation rate after chemoradiation - To evaluate the toxicity and complications of treatment with induction chemotherapy followed by ePLND and chemoradiation
Here, we postulate that the balance between the effect of belatacept on regulatory T-cell function and the relative insensitivity of memory T-cells for belatacept leads to donor-specific alloreactivity. We plan to study the peripheral CD28-dependent…
To compare the effect of oxygenated versus non-oxygenated hypothermic machine perfusion of grafts of DCD category III (awaiting circulatory death - controlled), kidneys aged 50 years or older on kidney graft function.
Primary Objective To compare tacrolimus dosing of the new Envarsus®-based immunosuppressive regimen with current clinical practice over 6 months following de novo renal transplantation in a real-life setting in different European Countries.…
To investigate if [18F]FB-IL2 PET/CT is able to detect acute allograft rejection in kidney transplantation patients.
To assess out to one-year the clinical status of patients who completed the double-blind part B of the 6-month study period in the Opsona phase II protocol (OPN305-102) by recording the following:• Incidence of biopsy-proven allograft rejection or…
Primary Objectives:*Phase 0: To determine the receptor occupancy of OPN-305 1.5mg/kg in patients receiving an ECD, DCD or SCD(CIT>18h) kidney transplantation and to verify the doses of OPN-305 to be used in Part A of the study.*Part A: to…
To find out if there is a protective effect of postconditioning on ischemia reperfusion-injury in kidneytransplantation.
The principal objective of the trial is to investigate whether the sequence of the nephrectomy in patients who receive sunitinib has an effect on patient outcome.
exclusion or demonstration of a diverticulum in patients undergoing a laparoscopic pull-through
This pilot study focuses on feasibility and will answer questions on safety of the procedure. Can a *Critical view of Safety* of the hilum of the kidney be ascertained in all anatomical variations.The findings of this study will be used to design a…
The feasability of a randomized trial studying the advantageous effects of low-pressure pneumoperitoneum during laparoscopic donornephrectomy will be assessed.
To compare the diagnostic performance of new lymph node staging methods for prostate cancer (dwMRI fused with 18F-Choline PET-CT) with the current gold standard of staging, the extended pelvic lymph node dissection (ELND)
To test the efficacy of renal sympathetic denervation therapy with a special focus on preservation of renal allograft function.
Primary : - to assess the safety and tolerability of a single ascending intravenous iv infused doses of OPN-305 in healthy subjects- determination of dose and infusion time for Phase II studiesSecondary : - to determine the pharmacokinetic profile…
To evaluate the safety and activity of BB3 compared to placebo in improving renal function in the immediate post-transplant period in patientswho have received a DCD kidney transplantation.
Primary Objective: -To compare metabolic activity and efficiency directly after transplantation in living and deceased donor kidney grafts. Secondary Objective(s): -To assess whether the contribution of aerobic and anaerobic metabolism differs…
Demonstrate the ability of OCT to distinguish malignant renal tissue from benign (normal) renal tissue by means of attenuation-coefficient.
Serum hepcidin levels are elevated in hemodialysis patients and may contribute to functional iron impairment and thus to ESA-resistance. Kinetics of hepcidin in hemodialysis patients has not been studied in detail. This study is designed to provide…