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Targeted vessel ablation of type 3 uterine fibroids with magnetic resonance guided high intensity focused ultrasound

To investigate whether it is possible to manipulate perfusion in type 3 fibroids with MR-HIFU.

Patient controlled analgesia i.v. with morphine versus continuous epidural analgesia with bupivacaïne and sufentanil as pain relief after caesarean section.

We would like to research wether there is a difference in time of mobilization between women getting iv PCA with Morphine (PCA)as opposed to women getting continuous epidural analgesia (CEA)with bupivacaine and sufentanil.We expect that the PCA will…

Acute Study to Evaluate a Novel Implantable Midfield Powered Device in Humans with Urinary Incontinence

Primary Objective 1:Verfiy that energy can be transmitted from an external unit to the NSM AHLeveeS System, through a wireless connection, resulting in stimulation of the S3 sacral nerve.Primary Objective 2:Confirm that the NSM AHLeveeS System can…

A randomized, single blinded trial to evaluate the efficacy of Imiquimod in women with residual/recurrent Cervical Intraepithelial Neoplasia (CIN) after previous treatment

Primary objectives: Evaluation of the efficacy of imiquimod 5% cream compared to treatment with Large Loop excision of the transformation zone (LLETZ) for recurrent/residual CIN.Secondary objectives: evaluation of the effect of treatments on HPV DNA…

Efficacy of revision of mesh surgery in patients with complications after treatment with vaginal synthetic mesh.

To evaluate the subjective and objective cure after surgical re-intervention due to mesh complications in our clinical setting in order to optimize therapy.

Laparoscopic advanced Imaging Techniques in Endometriosis therapy: the LITE study. A pilot trial.

To determine which advanced image enhanced modality is the most feasible for the detection of endometriosis lesions, with respect to the specificity and sensitivity of the investigated modalities. To determine which imaging modality reveals more…

Evaluation of the Follow me mode of the AutoLap system- a feasibility study

The main objectives of this study are to evaluate the performance and ease of use of the Follow me mode of the AutoLap system during general and gynecological laparoscopic procedures.Study Procedures: No. & type. A total of 35 laparoscopic…

Prospective randomized trial to evaluate and to compare the impact of hysteroscopic Essure® intratubal device placement and laparoscopic salpingectomy on IVF-ET outcomes of patients with hydrosalpinx.

1. To evaluate and compare the impact of hysteroscopic Essure® intratubal device placement and laparoscopic salpingectomy on IVF-ET outcomes of patients with hydrosalpinx.2. It is still uncertain whether laparoscopic salpingectomy for hydrosalpinx…

Hysterectomy with TUbectomy (HYSTUB) study

Does salpingectomy during a hysterectomy cause POF? Secundary: what is the incidence of premalignant changes within Fallopian tubes of women without a hereditary high risk to develop serous carcinoma?

Follow-Up after feToscopic sURgical intErventions: the FUTURE study

Both RCTs and long-term follow-up studies are required to establish optimal fetal management and provide clinicians a better understanding of the impact of these early interventions on child development in order to improve the quality of antenatal…

Long-term follow-up of the prospective and comparative study of the performance of tension free vaginal mesh (ProliftTM) versus conventional pelvic organ prolapse surgery in recurrent prolapse

To asses the effectiveness of surgery 7 and 10 years after conventional vaginal POP surgery compared with tension free vaginal mesh.

Obstetric anal sphincter injury, a follow-up study on the long term outcome.

Aim of the study is to get informed on the outcome of women treated in the MUMC for obstetric anal sphincter injury between 2005 and 2012. The controlgroup is matched for maternal age at delivery, parity, mode of delivery and child weigth.

RCT comparing insertion of levonorgestrel releasing intrauterine system (Mirena) during the menstruation compared with random insertion beyond menstruations in patient-perceived pain.

In this randomized study, timing during (day 1-7 of the menstruation cycle WITH vaginal blood loss) or beyond menstruation (in menstruation cycle day 8 and further WITHOUT vaginal blood loss) will be compared regarding differences in patient-…

An observational controlled study on vaginal blood flow, sexual functioning, bladder and bowel function after radiation therapy following nerve-sparing radical hysterectomy for early stage cervical cancer (FIGO IA2-IIA).

In this controlled (studygroups from P05-095 will serve as controls) observational study, the effects of radiation therapy after nerve-sparing radical hysterectomy for early stage cervical cancer on sexual function, bladder and bowel function is…

Pelvic organ mobility after treatment for uterine descent

The primary objective is to assess the differences in mobility of pelvic organs between three commonly performed treatment options for uterine descent (vaginal hysterectomy, vaginal sacrospinous hysteropexy and laparoscopic sacrohysteropexy). The…

STATEC: A randomised trial of non-selective versus selective adjuvant therapy in high risk
endometrial cancer

To determine the clinical effectiveness of adjuvant therapy given to all unstaged (no lymph node dissection) high risk stage 1 endometrial cancer, compared with only node positive (staged) cases as judged by full lymph node dissection.

Pretherapeutic para-aortic lymphadenectomy in advanced stage cervical cancer.

1. To study the safety and feasibility of para-aortic surgical staging in advanced cervical cancer in the Netherlands.2. To provide insight in the possible effectiveness of para-aortic surgical staging in advanced cervical cancer as compared to…

Pivotal Study for Safety & Efficacy of AltaSeal® A Hysteroscopically Placed Mechanical Occlusion Implant for Hysteroscopic Sterilisation

The primary objective of this clinical trial is to evaluate the safety and effectiveness of the AltaSeal® implants in providing bilateral mechanical occlusion of the fallopian tubes and in preventing pregnancy.Additional objectives are as follows:*…

Sexual complaints in female cancer survivors: Is there a need for treatment?

Observational multicenter trialThe following research questions (Q) will be addressed in patients (and partners) (Q1) whether sexual problems as reported by female cancer survivors are personally distressing and if so, ( Q2) what are possible…

Prospective study on the treatment of congenital vaginal agenesis or vaginal hypoplasia - genital reconstruction, gynecological and urological aspects, psychosexual and social aspects and quality of life

Evaluation study on the effectiveness of a new developed vaginal dilatation programme for medical-psychological treatment of vaginal hypoplasia / agenesis.