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A randomized controlled trial comparing paracervical block with a combination of paracervical block and fundal anesthesia during endometrial ablation in the outpatient clinic.

To compare a combination of paracervical anesthesia and fundal anesthesia with paracervical anesthesia only during endometrial ablation.

Targeted vessel ablation of type 3 uterine fibroids with magnetic resonance guided high intensity focused ultrasound

To investigate whether it is possible to manipulate perfusion in type 3 fibroids with MR-HIFU.

Acute Study to Evaluate a Novel Implantable Midfield Powered Device in Humans with Urinary Incontinence

Primary Objective 1:Verfiy that energy can be transmitted from an external unit to the NSM AHLeveeS System, through a wireless connection, resulting in stimulation of the S3 sacral nerve.Primary Objective 2:Confirm that the NSM AHLeveeS System can…

A randomized, single blinded trial to evaluate the efficacy of Imiquimod in women with residual/recurrent Cervical Intraepithelial Neoplasia (CIN) after previous treatment

Primary objectives: Evaluation of the efficacy of imiquimod 5% cream compared to treatment with Large Loop excision of the transformation zone (LLETZ) for recurrent/residual CIN.Secondary objectives: evaluation of the effect of treatments on HPV DNA…

Efficacy of revision of mesh surgery in patients with complications after treatment with vaginal synthetic mesh.

To evaluate the subjective and objective cure after surgical re-intervention due to mesh complications in our clinical setting in order to optimize therapy.

Evaluation of the Follow me mode of the AutoLap system- a feasibility study

The main objectives of this study are to evaluate the performance and ease of use of the Follow me mode of the AutoLap system during general and gynecological laparoscopic procedures.Study Procedures: No. & type. A total of 35 laparoscopic…

Prospective randomized trial to evaluate and to compare the impact of hysteroscopic Essure® intratubal device placement and laparoscopic salpingectomy on IVF-ET outcomes of patients with hydrosalpinx.

1. To evaluate and compare the impact of hysteroscopic Essure® intratubal device placement and laparoscopic salpingectomy on IVF-ET outcomes of patients with hydrosalpinx.2. It is still uncertain whether laparoscopic salpingectomy for hydrosalpinx…

Hysmis Study
Misoprostol for cervical priming prior to hysteroscopy in postmenopausal or nulliparous women;
a multi-centre randomised placebo controlled trial

To evaluate the benefit of Misoprostol prior to hysteroscopy in nulliparous and postmenopausal women regarding the reduction of pain

Long-term follow-up of the prospective and comparative study of the performance of tension free vaginal mesh (ProliftTM) versus conventional pelvic organ prolapse surgery in recurrent prolapse

To asses the effectiveness of surgery 7 and 10 years after conventional vaginal POP surgery compared with tension free vaginal mesh.

Obstetric anal sphincter injury, a follow-up study on the long term outcome.

Aim of the study is to get informed on the outcome of women treated in the MUMC for obstetric anal sphincter injury between 2005 and 2012. The controlgroup is matched for maternal age at delivery, parity, mode of delivery and child weigth.

RCT comparing insertion of levonorgestrel releasing intrauterine system (Mirena) during the menstruation compared with random insertion beyond menstruations in patient-perceived pain.

In this randomized study, timing during (day 1-7 of the menstruation cycle WITH vaginal blood loss) or beyond menstruation (in menstruation cycle day 8 and further WITHOUT vaginal blood loss) will be compared regarding differences in patient-…

An observational controlled study on vaginal blood flow, sexual functioning, bladder and bowel function after radiation therapy following nerve-sparing radical hysterectomy for early stage cervical cancer (FIGO IA2-IIA).

In this controlled (studygroups from P05-095 will serve as controls) observational study, the effects of radiation therapy after nerve-sparing radical hysterectomy for early stage cervical cancer on sexual function, bladder and bowel function is…

Pelvic organ mobility after treatment for uterine descent

The primary objective is to assess the differences in mobility of pelvic organs between three commonly performed treatment options for uterine descent (vaginal hysterectomy, vaginal sacrospinous hysteropexy and laparoscopic sacrohysteropexy). The…

Prospective study on the treatment of congenital vaginal agenesis or vaginal hypoplasia - genital reconstruction, gynecological and urological aspects, psychosexual and social aspects and quality of life

Evaluation study on the effectiveness of a new developed vaginal dilatation programme for medical-psychological treatment of vaginal hypoplasia / agenesis.

A randomized controlled multicenter phase III trial comparing cytoreductive surgery followed by intravenous chemotherapy versus intravenous chemotherapy alone for recurrent platinum-sensitive ovarian cancer

There is still no level I-II evidence for cytoreductive surgery in recurrent ovarian cancer. This is also the conclusion of a Cochrane Review of Galaal et al. published in June 2010. The most active chemotherapy in platinum sensitive recurrent…

A PROSPECTIVE AND COMPARATIVE STUDY OF THE (COST) EFFECTIVENESS OF TENSION FREE VAGINAL MESH PLUS MONOCRYL (PROLIFT+MTM) VERSUS CONVENTIONAL VAGINAL PROLAPSE SURGERY IN PRIMARY PROLAPSE

To compare the clinical and cost effectiveness of the Tension free Vaginal Mesh + Monocryl (Prolift+MTM) with the standard vaginal prolapse surgery (i.e. fascial placation). A secondary objective is to track the post-operative and long-term…

Safety and Performance Evaluation for the AEGEA Global Endometrial (GEA) System in Women Scheduled to Undergo a Hysterectomy.

The purpose of this study is to demonstrate that the use of the Vapor System is safe and effective. It will be tested in patients who were already planned to undergo a hysterectomy and the device thus has no therapeutic purpose in this particular…

Effect of reconstructive surgery on circumsized women well-being: a follow-up study

The primary aim of this study is to gain more insight on the impact of reconstructive surgery on circumcised women (type I, 2 & 3). This study may also used for theorizing about plastic surgery on women who are circumcised.

Transvaginal mesh repair of recurrent vaginal prolaps (prolift technique); a cross sectional study of 65 cases in a Dutch teaching hospital.

1. to measure anatomical outcome after vaginal repair with mesh (Prolift technique) and compare with pre-operative scorings, using POP-Q test.2. to estimate quality of life, sexual functioning, urogenital en defecatory symptoms after vaginal repair…

Sacrospinous ligament fixation versus Elevate Posterior procedure in treatment of primary apical prolapse stage * 2: a multi-center randomised controlled trial.

To compare the effects of Elevate Posterior procedure versus sacrospinous ligament fixation on pelvic floor function.