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Transfusion of fresh frozen plasma in non bleeding ICU patients

With the aim to restrict inappropriate FFP transfusions to critically ill patients, a randomized clinical trial will be conducted in a subgoup of ICU patients undergoing an invasive procedure. The objective is to assess the effectiveness and costs…

The effect of a preoperative lifestyle intervention in patients with acquired risk factors on perioperative glucose control and hemodynamics

The primary objective of this study is to investigate whether skeletal muscle glucose metabolism, perioperative glucose control and hemodynamics are affected by increasing physical activity in the weeks preceding surgery in patients identified with…

Catheter ablation versus Amiodarone to pRevent Future ventricular tachycardia Episodes in patients with a defibrillator and a history of a myocardial infarction

Time to recurrence of sustained VT and/or appropriate ICD therapy; ATP or shock

The effect of prewarming on hypothermia during orthopaedic surgery and related postoperative complications.

In this present study we will assess the effect of a pre-warming intervention before surgery, in order to decrease the temperature gradient from core to periphery and thereby minimize redistribution hypothermia under anesthesia, on (I) the…

An assessment of the association between fatigue, physical activity, psychological wellbeing and quality of life in breast cancer patients during and shortly after adjuvant chemotherapy

The objective of this study is to assess fatigue, physical activity, psychological wellbeing and quality of life in breast cancer patients during and shortly after adjuvant chemotherapy. We will study how often en how intense the symptoms occur. We…

Predicting fracture risks in patients with metastatic bone defects: a multicenter prospective observational study. NWO STW Veni grant NPG.6778

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Effect of a negative pressure dressing (Prevena TM) on the prevention of wound dehiscence in clean closed surgical incisions: a rondomized controlled trial.

The aim of this study is to compare the effectiveness of a negative pressure dressing (Prevena (TM) IMS) with a standard wound dressing (care as usual) in clean closed surgical wounds on the prevention of wounddehiscence in patients, undergoing an…

Preventive Heart Rehabilitation in patients undergoing elective Open heart surgery to prevent Complications and to improve Quality of life (Heart-ROCQ) - A randomized controlled trial

to determine whether a pre- and postoperative CR (PRE+POST) program improves the short (up to three months) and long term outcomes (up to one year) after cardiac surgery (i.e. reduction in postoperative surgical complications, readmissions to…

Preoperative home-based multimodal prehabilitation in patients scheduled for liver or pancreatic resection

The primary objective is to assess the (preliminary) effectiveness of a 4-week home-based exercise training program on an advanced cycle ergometer and the administration of nutritional supplements on preoperative aerobic capacity as measured by the…

A multi-center randomized controlled study of primary prevention of esophageal variceal bleeding in cirrhotic patients treated with HVPG-guided beta- blocker therapy or standard heart rate-guided beta-blocker therapy.

To determine cost-effectiveness of hepatic venous pressure gradient (HVPG)-guided nonselective beta-blocker therapy as compared to standard heart rate-guided beta-blocker therapy in the primary prevention of esophageal variceal bleeding in cirrhotic…