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Phase III trial comparing conventional adjuvant Temozolomide with dose-intensive Temozolomide in patients with newly diagnosed glioblastoma

To determine if dose-intensifying the adjuvant temozolomide component of the chemoradiation treatment enhances treatment efficacy as measured by overall survival.

Dexamethasone (DXM) therapy in symptomatic patients with chronic subdural hematoma (DECSA- Trial). Effect of initial corticosteroid therapy versus primary surgery on clinical outcome.

Primary objective: To assess the effect-of initial DXM therapy versus primary surgery on functional outcome (as expressed by the mRS) and costs in patients with a newly diagnosed CSDH respectively after 3 and 12 months.Secondary objectives are:…