113 results
This study will assess the applicability of robotic-assisted microsurgery in DNR after trauma.
To determine if the incidence of adverse local events (local failure or radionecrosis) can be reduced with more than 20% using fSRT versus SRT in one or three fractions.
[Retrospective clinical path:1) main objective: to identify predictors (sociodemographic, clinical, imaging, and (neuro)psychological variables) of objective cognitive functioning of all patients who undergo neurosurgyer, at 3 months after surgery2…
The purpose of this post-approval protocol amendment is to extend the follow-up of subjects who were originally enrolled in theRCT, EUBARD-CP_001 protocol. This study extension will examine the long-term survivorship of the Barricaid® ACD when…
Firstly, to assess the ability of fUS to discriminate between functional and non-functional brain areas using task-specific brain-activity during an awake neurosurgical procedure. Secondly, to assess the ability of fUS to discriminate between…
Research question(s). There are two specific questions to be addressed:1) Is percutaneous transforaminal endoscopic discectomy (PTED) no worse in effectiveness than conventional unilateral open microdiscectomy for patients with symptomatic…
Primary objective of this clinical investigation is to evaluate superiority of the signal quality of SOFT ECoG flexible high-density electrode grids compared to regular high-density electrode grids, routinely used at the UMC Utrecht. The signal…
This study has been transitioned to CTIS with ID 2024-510767-30-00 check the CTIS register for the current data. 1. To determine the feasibility of SGM-101 for intraoperative imaging of colorectal brain metastases - Concordance between fluorescent…
To assess the proportion of lumbar spinal stenosis surgical treatment plans that change when an objective measurement of spinal stability is included and applied following a simple treatment algorithm
Primary objective: To assess the effect-of initial DXM therapy versus primary surgery on functional outcome (as expressed by the mRS) and costs in patients with a newly diagnosed CSDH respectively after 3 and 12 months.Secondary objectives are:…
Primary: To evaluate whether additional embolization of the middle meningeal artery after surgery for cSDH reduces the recurrent surgery rate. Secondary: to evaluate whether the use of middle meningeal artery embolization after surgical treatment in…
There is a high degree of diversity in attributed risk on thrombosis in the neurosurgical patient cohort. Due to this diversity, insufficient power of performed studies and lack of careful phenotyping and description of risk factors in previous…
In this project we aim to develop a safe and effective technique for ADC/FET-guided resection of IDH-wildtype glioblastoma and grade IV IDH-mutant astrocytoma. The safety concerns neurological deficits and time to start of adjuvant therapy, while…
Identifying the (immune) cell composition, co-localization, functions, and alterations as well as blood and lymph vessels reorganisation in the human*s dura, arachnoid and pia mater, and skull bone marrow in high-grade glioma patients as compared to…
The primary objective of the proposed research is to investigate in patients with PDD the efficacy of STN-DBS with best oral medical treatment (DBS-group) for disabling motor symptoms during off-drug phase compared to best oral medical treatment…
To determine the value of and generate the clinical evidence for routine application of Whole Genome Sequencing (WGS)-based diagnostics and targeted therapy guidance for glioblastoma patients at time of first recurrence.
This study has been transitioned to CTIS with ID 2024-515128-35-00 check the CTIS register for the current data. The primary objective is:• To evaluate the safety and tolerability of a single local i.c. dose of SI-053 to establish the MTD and/or the…
To develop a deep learned super-resolution model that predicts high-resolution images with a peak signal-to-noise ratio of 37dB or higher.
The primary research question of the trial is to assess whether foot drop, caused by peroneal nerve entrapment in adult patients* recovers better within 9 months after decompressive surgery compared to prolonged standard conservative treatment. *…
Primary Objective: For the primary objective, the following research question is answered: Does performing asleep thalamic DBS provide an equal reduction in tremor compared to awake thalamic DBS, measured by the Essential Tremor Rating Assessment…