113 results
This study has been transitioned to CTIS with ID 2024-516338-37-00 check the CTIS register for the current data. This study aims to assess the Pharmacokinetic (PK)-parameters and safety of treatment with BR-003 in humans. BR-003 is a pliable, ring-…
The purposes of this study are to uncover1. Which surgical methods are least likely to cause the CMS and if there is a difference in risk between primary surgery andreoperation2. Which patients may be genetically predisposed to developing the CMS 3…
The aim of this study is to determine whether VR used during lumbar puncture will significantly reduce pain and anxiety perception.
1. To study whether minimally invasive endoscopy-guided surgery, in addition to standard medical management, for the treatment of spontaneous supratentorial ICH performed within 8 hours of symptom onset, improves functional outcome in comparison…
Evaluation of longterm clinical and radiological results.
The objective of the study is to clinically assess the safety and performance of the Dura Sealant Patch as a means of reducing intra- as well as post-operative CSF leakage in patients undergoing elective cranial intradural surgery with a dural…
The study will take place in 5 neurosurgical centers in the Netherlands (Erasmus MC, UMC Utrecht, Elizabeth Ziekenhuis Tilburg, MC Haaglanden The Hague, UMCG Groningen) and one center in Belgium (UZ Gent). All centers have ample experience with the…
The primary aim of this study is to investigate if these innovative surgical solutions are effective in maintaining curve reduction without repeat lengthening procedures and complications. Secondary aims are to investigate growth of the instrumented…
Overall ObjectiveThe purpose of the study is to compare the effect of craniotomy and tumor resection followed by adjuvant second-line therapy to no surgery followed by second-line therapy on overall survival, neurological status, and quality of life…
To document whether patients treated with minimally invasive surgery experience less back pain at 2 and 6 weeks after surgery, compared to patients treated with conventional open instrumented surgery.
The primary objective of this clinical pilot study is to explore the feasibility of Flatpanel Detector - Parenchymal Blood Volume (FD-PBV) imaging in patients with intracranial meningiomas during neurosurgery in the Hybrid-OR. Image quality, added…
To assess the change in Intra-Abdominal Pressure (IAP), measured via indwelling urinary catheter, when using the IPS for positioning a subject in prone position for spine surgery.
In this non-inferiority trial, we aim to demonstrate that 3D-printed guides are just as good as CAS, regarding the postsurgical radiological screw-insertion accuracy.
Primary Objective: To optimize the current DBS-treatment of advanced PD. For the primary objective the following research questions will be answered: By performing STN DBS under general anesthesia, will there be a significant reduction in cognitive…
To determine the effective dose ED90 of Chloroprocaine for patients undergoing knee arthroscopy.
The primary objective of this randomized controlled trial is to determine whether decompressive surgery and best medical treatment in patients with spontaneous ICH will improve outcome compared to best medical treatment only. Secondary objectives…
The primary objective is to determine the limited-efficacy of both the experimental systems in comparison to our previous cohort that was treated with the more traditional MCGR. Limited-efficacy will be determined in terms of maintenance of the…
The objectives of STIMO-2 are to demonstrate the safety and feasibility and to obtain preliminary evidence on the effectiveness of mobility rehabilitation facilitated by TESS to improve neurological recovery when this intervention is delivered in…
To determine the presence and predictive value of MLE on cognition after DBS in PD.
The purposes of this study are to uncover- Which clinical and neuroradiological measures can be used to predict the (neuropsychological) outcome and progression of symptoms in children with CMS?We hope that the results will contribute to an overall…