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Clonidine as Additive for Locoregional Postoperative Analgesia in
Foot and Anckle Surgery

Extending Popliteal block duration with adding clonidine to the levobupivacaine (= standard care)

A Randomized Controlled Trial of AttraX® Putty vs. Autograft in Instrumented Posterolateral Spinal Fusions

The primary objective of this study is to demonstrate the non-inferiority of AttraX® Putty as a bone graft substitute for autograft in instrumented posterolateral fusion of the thoracolumbar spine, in terms of efficacy and safety.

Chloroprocaine vs prilocaine for spinal anaesthesia in day-case surgery: a double-blind randomized trial

To investigate effectiveness of spinal chloroprocaine, and prilocaine in day case surgery. The null hypothesis is that there is no significant intergroup difference in complete recovery from motor blockade.

A phase I, randomised, double-blind, placebo-controlled study in patients with amyotrophic lateral sclerosis to further assess the safety and tolerability of intracerebroventricular administration of sNN0029 infusion solution.

The objective of the trial is to assess the safety and tolerability of i.c.v. administration of sNN0029 infusion solution at a dose of 4 µg per day delivered via a Medtronic SynchroMed® II Infusion System.

Percutaneous Cervical Nucleoplasty vs. Pulsed Radio Frequency in patients with contained cervical disc herniation; a double-blind randomized clinical trial

To investigate which technique is the most effective in terms of pain relief on short term in patients with contained cervical disc herniation: PCN or PRF?

Fibrinogen therapy for massive blood loss during elective surgery for craniosynostosis repair, a double blinded randomized controlled study

Primary outcome parameter is the amount of intra- and postoperative transfusions required. Secondary outcome parameters include intra- and postoperative blood loss, operation time, and postoperative complications and the outcome of…

Focal Pain Outcomes using Configurations Applied for Lateral Stimulation

To evaluate Multiple Independent Current Control (MICC) perception and sub-perception based programming at Dorsal Column (DC) targets and Dorsal Root (DR) targets for focal foot, knee, or groin pain relief.

The influence of electroencephalographic density spectral array guidance of sevoflurane administration on recovery from general anaesthesia in children between 6 months and 12 years.

To evaluate the influence of DSA monitoring, provided by the NarcotrendTM monitor, on the speed of emergence and recovery from GA.

Tranexamic Acid to Prevent Operation in Chronic Subdural Hematoma

This study has been transitioned to CTIS with ID 2024-514927-40-02 check the CTIS register for the current data. To evaluate the efficacy of TXA to prevent surgery for cSDH

The effectiveness of endolymphatic duct blockage versus endolymphatic sac decompression in patients with intractable Ménière*s disease

This study assesses whether EDB surgery will result in a significant reduction in the number of patients without vertigo spells at 12 months follow up, compared to patients who undergo endolymphatic sac decompression.

The effect of perioperative intravenous s-ketamine on acute and chronic postoperative craniotomy pain compared to placebo

This study has been transitioned to CTIS with ID 2024-514020-16-00 check the CTIS register for the current data. To investigate the effectiveness of s-ketamine as add-on medication to a multimodal pain approach with acetaminophen and opioids…

a Randomized controlled trial for epidural Analgesia for Pain relief after lumbar Interlaminar Decompressive spine surgery - RAPID

To determine whether intraoperative epidural analgesia is superior to placebo in reducing wound pain in patients after decompressive lumbar spine surgery, and to determine whether opioid use in the 2 days after surgery is significantly higher in the…

Effectiveness of neurolysis versus neurectomy of the lateral femoral cutaneous nerve (LFCN) in the treatment of meralgia paresthetica.

The goal of the stomp trial will be to investigate the effectiveness of both the neurolysis and neurectomy procedure in patients with persistent symptoms of meralgia paresthetica. In addition, in this trial we want to determine to what extend…

ReActiv8 Implantable Neurostimulation System for Chronic Low Back Pain

To evaluate the safety and efficacy of ReActiv8 for the treatment of adults with Chronic Low Back Pain and no prior spine surgery when used in conjunction with medical management.

A Randomized, Double-blind, Placebo-controlled, Multicenter Efficacy Study of the Gelstix* Device to treat Chronic Discogenic Low Back

The primary objective of this study is to quantify the reduction in lumbar pain in a GelStix* treatment group compared with a control group receiving a saline solution injection as placebo.The secondary objectives are to assess: 1. the impact of…