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Clonidine as Additive for Locoregional Postoperative Analgesia in
Foot and Anckle Surgery

Extending Popliteal block duration with adding clonidine to the levobupivacaine (= standard care)

Interbody fusion in the treatment of cervicobrachial syndrome; a prospective trial of porous titanium cervical cages.

Documentation of the patients' functional recovery and quantification of fusion after implantation of 3-D trabecular titanium cages on the short and long term. These data will be compared with the recently performed randomized CASCADE trial on…

Focal Cortical Dysplasias and Epilepsy: Characteristics of Histopathology and 7 tesla MRI.

In this study one of the goals is to compare 7 tesla MRI with 3 tesla MRI in terms of lesion detection in epilepsy patients and depiction of specific dysplasia-related imaging characteristics. Furthermore, resected tissue will be scanned ex-vivo at…

Evaluation of Intraoperative and early postoperative Growth Hormone Levels for Transsphenoidal Resection in Acromegaly

Determination of prognostic value of intraoperative growth hormone levels on postoperative curation for acromegaly in patients undergoing transsphenoidal resection of pituitary adenoma.

Does size matter? Clinical outcome related to the extent of posterior (cranio)cervical fixations. A prospective international multicenter study.

A study on extent-related outcome and complications for degenerative cervical spinal disease has not yet been performed. Results of this study may form the basis for a guideline regarding the extent of fixation in degenerative cervical spinal…

Functional outcome one year after osteoporotic vertebral compression fractures

Primary objective:1. To assess functional outcome of patients with an osteoporotic vertebral compression fractures after one year of follow-up.Secondary objectives:1. To assess radiological deterioration of sagittal alignment during one year of…

A Randomized Controlled Trial to Evaluate the Efficacy of Pulsed Radiofrequency as a Treatment for Anterior Cutaneous Nerve Entrapment Syndrome in comparison to Anterior Neurectomy

Primary objective is to study the number of patients gaining at least 50% pain reduction within 8 weeks following PRF as compared to following a neurectomy. Pain intensity will be measured using numeric pain rating score (NPRS, 0-10) and Verbal…

The Anterior Cutaneous Nerve Entrapment Syndrome (ACNES).
Retrograde transforaminal paresthesia mapping (RTPM) for patients with ACNES. A pilot study for the anatomical distribution of neuropathic pain in the trunk at the level of
the dorsal root ganglion.

This mapping study will contribute to our understanding of the pathogenesis of ACNES and the complex anatomical distribution of sensory input of the trunk. It will also pave the way for a better diagnostic work-up, allowing for better surgical…

(Cost) effectiveness of open Microdiscectomy vs. percutaneous transforaminal endoscopic discectomy (PTED) for patients with lumbosacral radicular syndrome due to a lumbar disc herniation

Research question(s). There are two specific questions to be addressed:1) Is percutaneous transforaminal endoscopic discectomy (PTED) no worse in effectiveness than conventional unilateral open microdiscectomy for patients with symptomatic…

Deep Brain Stimulation in Patients with Chronic Treatment Refractory Anorexia Nervosa: a Pilot Study

The aims of this research project are:1) to establish the efficacy and feasibility of DBS as a last resort treatment in patients with chronic, treatment refractory AN. 2) to associate the efficacy and functional effects of DBS in patients with…