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1. To study whether minimally invasive endoscopy-guided surgery, in addition to standard medical management, for the treatment of spontaneous supratentorial ICH performed within 8 hours of symptom onset, improves functional outcome in comparison…
Evaluation of longterm clinical and radiological results.
The primary objective is to demonstrate non-inferiority of MagnetOsTM Granules compared to autograft in instrumented posterolateral spinal fusion, in terms of efficacy and safety by means of an intra-patient model.
The study will take place in 5 neurosurgical centers in the Netherlands (Erasmus MC, UMC Utrecht, Elizabeth Ziekenhuis Tilburg, MC Haaglanden The Hague, UMCG Groningen) and one center in Belgium (UZ Gent). All centers have ample experience with the…
The primary aim of this study is to investigate if these innovative surgical solutions are effective in maintaining curve reduction without repeat lengthening procedures and complications. Secondary aims are to investigate growth of the instrumented…
Overall ObjectiveThe purpose of the study is to compare the effect of craniotomy and tumor resection followed by adjuvant second-line therapy to no surgery followed by second-line therapy on overall survival, neurological status, and quality of life…
To document whether patients treated with minimally invasive surgery experience less back pain at 2 and 6 weeks after surgery, compared to patients treated with conventional open instrumented surgery.
To determine whether intraoperative epidural analgesia is superior to placebo in reducing wound pain in patients after decompressive lumbar spine surgery, and to determine whether opioid use in the 2 days after surgery is significantly higher in the…
In this non-inferiority trial, we aim to demonstrate that 3D-printed guides are just as good as CAS, regarding the postsurgical radiological screw-insertion accuracy.
Primary Objective: To optimize the current DBS-treatment of advanced PD. For the primary objective the following research questions will be answered: By performing STN DBS under general anesthesia, will there be a significant reduction in cognitive…
To determine the effective dose ED90 of Chloroprocaine for patients undergoing knee arthroscopy.
Currently the available data on cost and clinical effectiveness of TLIF compared to PLIF for patients with lumbar spondylolisthesis is not sufficient. With a steep increase in instrumented spinal fusion, and an expected further increase in the…
The primary objective of this randomized controlled trial is to determine whether decompressive surgery and best medical treatment in patients with spontaneous ICH will improve outcome compared to best medical treatment only. Secondary objectives…
The primary objective is to determine the limited-efficacy of both the experimental systems in comparison to our previous cohort that was treated with the more traditional MCGR. Limited-efficacy will be determined in terms of maintenance of the…
The objectives of STIMO-2 are to demonstrate the safety and feasibility and to obtain preliminary evidence on the effectiveness of mobility rehabilitation facilitated by TESS to improve neurological recovery when this intervention is delivered in…
To determine the presence and predictive value of MLE on cognition after DBS in PD.
The goal of the stomp trial will be to investigate the effectiveness of both the neurolysis and neurectomy procedure in patients with persistent symptoms of meralgia paresthetica. In addition, in this trial we want to determine to what extend…
To evaluate the safety and efficacy of ReActiv8 for the treatment of adults with Chronic Low Back Pain and no prior spine surgery when used in conjunction with medical management.
1. To study safety, feasibility and technical effectiveness of minimally-invasive endoscopy-guided surgery for treatment of supratentorial ICH; 2. To estimate the potential effect of minimally-invasive endoscopy-guided surgery on functional outcome…
The objective of this study is to determine the value of TOD (first rib resection with partial scalenectomy and neurolysis) on functionality and quality of life. We will do this by randomizing patients into who already received physiotherapy into…