31 results
The primary objective of this study is to establish the sensitivity and specificity of an oral uracil loading test as a potential screening tool for DPD deficiency
In this study the prevalence and kind of sexual and psychosexual problems will be assessed. Psychological well being is studied as well
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To evaluate the efficacy of TESE and to describe the risks of the TESE procedure for the men with a four year follow-up of their offspring.
To establish biomarkers in nipple aspirate fluid, follow them in time and link them to breast cancer development at its earliest stage in women at high risk for breast cancer. Threshold values of biomarkers will be determined that point to a…
- Identify key factors of the cardiac transcriptome in patients with cardiac malformations- Identify the transcriptional regulatory interactions underlying the cardiac transcriptome- Bioinformatically map and analyse the cardiac regulatory network…
To elucidate the molecular basis of skin disease.
To identify the determinants of psychological vulnerability through time (for the development of the prognostic risk profiles)
To determine, by measuring cIMT's, whether the abnormal lipid profile of GD I carriers and patients is associated with atherosclerosis and an increased risk of CAD.
The objective of the research is to examine the perspective of adults with Cystic Fibrosis concerning sexuality and to examine which factors are of influence, so that we 1.) acquire insight in giving meanings and perception of sexuality in the…
1. to investigate whether the known chronic inflammatory and hyperoxidative state in patients with severely increased LDL is associated with dysfunctional HDL.2. to investigate whether CVD in FH is associated with dysfunctional HDL.
To determine the frequency of symptoms and signs of a neuromuscular disorder (myopathy, neuropathy) in patients with haemochromatosis. To evaluate in these patients the impact of these symptoms and signs on the quality of life. To assess in patients…
Primary objectives1. What is the pulmonary function and exercise tolerance in children born with esophageal atresia at the age of 8-18 years (group I), determined by spirometry, measurement of lung volumes and a maximal exercise test. 2. What is the…
- To analyze retinoid levels in plasma and amniotic fluid from infants and mothers to establish the potential link between retinoids and CDH. - To establish a registry of blood and tissue samples that will be valuable for future studies of the…
The aims of this prospective study are to investigate:1a: Changes in menopausal symptoms and biochemical changes as result of PBSO in premenopausal women.1b: Changes in menopausal symptoms and biochemical changes as result of PBSO in postmenopausal…
To determine the feasibility and applicability of the intervention 'Traject' to improve the participation in work of young adults (16-25 years) with a chronic disorder.
Objectives Primary objective:- To determine if there is a difference in pro-hepcidin and hepcidin values in blood and urine between Gaucher patients and healthy controls, and between Gaucher patients and hemochromatosis patients. - To gain insight…
To determine the prevalence of α-Galactosidase A deficiency in male patients presenting with renal failure, proteinuria or micro-albuminuria of unknown cause, at the outpatient clinic of the department of internal medicine of a large teaching…
Our project focuses on the function of transporters and deiodinases in the (dys)regulation of intracellular T3 levels in patients with psychomotor retardation and abnormal serum thyroid hormone levels. The main objectives of our study are:1. To…
1. Does exercise training improve muscle function and exercise tolerance in patients with IPAH?2. Does exercise training in IPAH result in morphological and biochemical changes of the quadriceps muscle?3. Does exercise training in IPAH result in…