Search for a trial

The value of ultrasound compared to magnetic resonance imaging in haemophilic arthropathy

The primary objective of this study is to establish the diagnostic accuracy of ultrasound assessment of the synovium in haemophilic arthropathy compared to MRI. Secondary objectives are (2A) to determine whether or not synovial hypertrophy on MRI is…

Verification of preoperative screening for bleeding tendency in patients that report bleeding symptoms

The main object is to evaluate the validity of a diagnostic screening package for bleeding tendency consisting of point-of-care devices when compared with the gold standard for bleeding tendency diagnosis.Other objects which will be investigated are…

Clinical validation of Factor VIII allo-antibody assays
in patients with hemophilia A.
The correlation of factor VIII antibodies, measured with different assays, on factor VIII survival in patients with severe haemophilia A.

zie bijlage

thrombin generation in plasma, the predictive value of endogenous thrombin generation (ETG)in relation to hypercoagulability and bleedingrisk

Assessing hereditary and aquired determinants of ETP. Evaluating the use of ETP as predictive stand alone test for recurrent DVT and bleeding complications due to anticoagulation therapy in comparisson with the current prediction methods.

I-chec - Identifying children with hereditary coagulation disorders

1. To evaluate the diagnostic accuracy of a newly developed pediatric BAT.2. To analyze the influence of age, sex and type of bleeding disorder on the total bleeding score and the score of individual bleeding items.

Development of a finger stick based whole blood micro-assay for the rapid detection of Von Willebrand Disease

Performance is the primary objective of this study and is defined as the ability of the in vitro diagnostic micro-assay to measure von Willebrand factor induced platelet aggregation in accordance with the golden standard diagnostic method, risto-…

Predictors of Bleeding Evaluation in Adult Hematologic Patients with Bleeding Tendencies
Patients with established bleeding disorders: The BePa verification study

To evaluate the diagnostic accuracy of the experimental tests to detect bleeding disorders and to evaluate whether or not they can be used for monitoring the effects of coagulant factor replacement therapy.

Ga-68-DOTA-(RGD)2 PET/CT: imaging angiogenesis in patients with arterio-venous malformations

The primary objective of this study is to assess the feasibility and safety to image αvβ3-integrin expression in patients with AVM using Ga-68-DOTA-(RGD)2 PET/CT.

Thermal stability of Pyruvate kinase In Red blood cells

Main objective: - To investigate pyruvate kinase thermal stability in haemoglobinopathies.Secondary objectives: - To investigate the possibility of stimulation of PK activity and thermal stability by use of allosteric activators- To investigate…

Follow-up Groningen antithrombin study

The purpose of this study is to identify a pathogenic or likely pathogenic variant in unresolved families with antithrombin deficiency.

Lymphomics; improving the understanding of the anatomy of the lymphatic system and the direction and velocity of lymph flow

To improve the knowledge and understanding of the (patho)physiology of lymph disorders Main objective: the anatomy of the central lymph vessels, the velocity and direction of lymph flow and its influencers and thoracic duct outlet location and…