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International randomized double blind clinical study evaluating the efficacy and safety of clopidogrel 0.2mg/kg once daily versus placebo in neonates and infants with cyanotic congenital heart disease palliated with a systemic-to-pulmonary artery shunt (e.g. modified Blalock Taussig shunt)

Primary:To evaluate the efficacy of 0.2 mg/kg/day of clopidogrel versus placebo for the reduction of all-cause mortality and shunt-related morbidity in neonates or infants with cyanotic congenital heart disease palliated with a systemic-to-pulmonary…

Heart failure and cardiac repair; genes for heart repair and plasticity

- Identify key factors of the cardiac transcriptome in patients with cardiac malformations- Identify the transcriptional regulatory interactions underlying the cardiac transcriptome- Bioinformatically map and analyse the cardiac regulatory network…

Evaluation of aortic elastic properties in the long-term follow-up of surgical and catheter interventional closure of the persistent ductus arteriosus

1. To identify the patients at risk for aortic aneurysms after PDA closure.We expect to find a decreased distensibility of the aorta in this subgroup of patients which will be examined by MRI. Besides the functional MRI study genetic testing of the…