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CeRebrUm and CardIac protection with Allopurinol in neonates with critical congenital heart disease requiring cardiac surgery with cardiopulmonary bypass

This study has been transitioned to CTIS with ID 2024-513041-37-00 check the CTIS register for the current data. Primary objective of this study is to significantly reduce relevant (moderate/severe) parenchymatous brain injury on postoperative MRI…

A CELL-based platform to study the role of the micRotubule network in pediatric inHeritable arrhYTHMia patients and Improve the effiCacy of drug treatment

Primary objectives: The first aim is to examine the role of microtubule network in electrical conduction, protein localization and function in induced cardiomyocytes from pediatric BrS patients, life threatening ventricular arrhythmia patients and…

A Prospective Randomised CompArative trial of SubcutanEous ImplanTable CardiOverter-DefibrillatoR ImplANtation with and without DeFibrillation Testing

The primary objective is to test the hypothesis that S-ICD implant without DFT with PRAETORIAN Score is non-inferior to S-ICD implant with DFT with regard to first shock efficacy in spontaneous events. The secondary objective is to evaluate the…

Four dimensional flow analysis of complex congenital heart disease

To determine whether 4D-flow CMR volume measurements are superior to 2D-PC CMR volume measurements by comparing the intra-class correlation between 2D-PC flow CMR stroke volume measurements in the MPA and multi-slice volumetric RV flow volume to the…

Resveratrol as potential aortic growth inhibitor in patients with Marfan Syndrome

The aim of the study is to obtain sufficient data on beneficial effects of Resveratrol on aortic aneurysm expansion rate and functional properties in patients with Marfan syndrome to justify a phase IIb or a phase III randomized trial.

A Randomized, Double blind, Placebo controlled Clinical Study to Evaluate
Mavacamten (MYK-461) in Adults with Symptomatic Obstructive
Hypertrophic Cardiomyopathy

Primary Objective* To compare the effect of a 30-week course of mavacamten with placebo on clinical response comprising of exercise capacity and clinical symptoms in participants with symptomatic obstructive hypertrophic cardiomyopathy (oHCM)…

Efficacy and safety of oral itraconazole in the reduction of epistaxis severity in hereditary hemorrhagic telangiectasia

5.1 Study hypothesisThe primary study hypothesis states that oral treatment with itraconazole will reduce the epistaxis severity score (ESS) due to the anti-angiogenic effects of itraconazole.5.2 Research question and primary outcomeWhat is the…

Fontan-velocity study: Four-dimensional blood flow MRI analysis in patients with a Fontan circulation

To visualize and quantify areas of dysfunctional flow in the TCPC and within the single ventricle in patients after a Fontan procedure and try to determine a relationship between these quantitative energetic parameters and adverse outcome.

Survival of Double Inlet Left Ventricle (DILV) Patients without Fontan Circulation: Intracardiac Anatomy and Hemodynamics, Functional Status and Quality of life

The primary objective of this study is to describe the intracardiac anatomy and hemodynamics of DILV patients without Fontan circulation using 4D MRI. Furthermore, the functional status and quality of life of these patients will be assessed and…

Advanced hemodynamic monitoring of the heart and fetal channels in newborn infants using ultrafast ultrasound blood flow imaging

The primary objective of this study is to optimize the ultrafast ultrasound flow imaging technique for intra and extra cardiac flow visualization in neonates. The secondary objectives are 1) to compare cardiac output determined using conventional…