Search for a trial

Vascular Ehlers-Danlos syndrome - the COL3A1 gene
A comprehensive natural history study

Primary Objective: Further delineation of the natural history and phenotype/genotype relation of vEDS pateints with a heterozygous pathogenic variant in the COL3A1 gene. Secondary Objectives: 1. reasons for referral for genetic analysis; 2. all…

A long term extension trial of the Phase III lipid-lowering trials to assess the effect of long term dosing of inclisiran given as subcutaneous injections in subjects with high cardiovascular risk and elevated LDL-C (ORION-8)

The primary objectives are to evaluate:-The effect of inclisiran treatment on the proportion of subjects achieving prespecified low densitylipoprotein cholesterol (LDL-C) targets at end of study (EOS)-The safety and tolerability profile of long term…

Electromechanical profiling of arrhythmogenic substrates and triggers in the long-QT syndrome

To identify arrhythmogenic electromechanical risk profiles in LQTS patients; in baseline conditions and during provocation; the recognition of risk profiles will improve risk stratification for sudden cardiac death.

Nitric Oxide during Cardio Pulmonary Bypass during surgery for congenital heart defects: A Randomised Controlled Trial.

Primary objective of this trial is to investigate in a double blind randomized controlled trial in children undergoing open heart surgery if NO exposure during CPB reduces the postoperative duration of invasive mechanical ventilation (defined as…

The PULSTA(TM) Transcatheter Pulmonary Valve (TPV) Pre-Approval Study

The primary objective is to evaluate the safety and effectiveness of the PULSTA TPV System for the treatment of congenital or acquired heart disease with pulmonary valve disease and to gain data that will lead to CE mark approval for the PULSTA TPV…

The influence of the menstrual cycle on diagnostic results of cardiovascular diseases - The Cycle Study II

To investigate whether the menstrual cycle influences diagnostics in patients with cardiovascular disease

Quality of Life 4: Long-term cardiological and psychosocial outcome in adults operated for congenital heart disease in early childhood: a longitudinal cohort-study of 40-53 years of follow-up.

This study will focus on the long-term outcome after surgical correction of several congenital heart defects in a non-selected cohort. The repetitive nature of this study will make it possible to analyze specific changes in cardiac function over…

mHealth in Grown-up Congenital Heart Disease

The aim of the proposed randomized controlled trial (RCT) is to determine the effectiveness, and related healthcare costs of a mHealth-based targeted clinical monitoring pathway in GUCH patients. The primary research question is to assess the effect…

A Long-term Safety Extension Study of Mavacamten (MYK-461) in Adults
with Hypertrophic Cardiomyopathy Who Have Completed the MAVERICKHCM
(MYK-461-006) or EXPLORER-HCM (MYK-461-005) Trials (MAVA-LTE)

This study has been transitioned to CTIS with ID 2022-502858-14-00 check the CTIS register for the current data. primary objective:To assess the long-term safety and tolerability of mavacamten in participants with hypertrophic cardiomyopathy (HCM)…

Ajmaline provocation in early detection of Arrhythmogenic Cardiomyopathy

Describe the electrocardiographic changes and areas of late myocardial activation encountered in PLN and PKP2 mutation carriers during ajmaline provocation and the relation of these differences to the development for early stages of arrhythmogenic…