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4D flow hemodynamics in the great arteries in children and adults after arterial switch operation for transposition of the great arteries

1. The application of 4D flow MR imaging to analyse blood flow patterns (flow angle, flow asymmetry), regional vessel wall parameters (regional wall shear stress, vessel wall thickness) and pulsed-wave velocity in neoaortic root, carotid artery and…

A Phase 2/3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effect of GS-6615 on Exercise Capacity in Subjects with Symptomatic Hypertrophic Cardiomyopathy

The primary objective of this study is to:* Evaluate the effect of GS-6615 on exercise capacity, as measured by Peak VO2 achieved during cardiopulmonary exercise testing (CPET), in subjects with symptomatic hypertrophiccardiomyopathy (HCM).The…

A multi-center, double-blind, randomized, placebo-controlled, parallel-group, Phase 3 study to evaluate the effects of macitentan on exercise capacity in subjects with Eisenmenger Syndrome.

To demonstrate that macitentan improves exercise capacity in comparison with placebo in subjects with Eisenmenger Syndrome (ES).

Exercise capacity in Tetralogy of Fallot: heart, lungs or muscles?

Primary Objective(s): - To determine the relation between CPET and pulmonary and muscular performance in patients with Tetralogy of Fallot.- To study the effect of previous lateral thoracotomy on pulmonary function and exercise.Secondary Objective(s…

Whole exome sequencing in patients with Idiopathic Ventricular Fibrillation and familial Atrial Fibrillation

Genotyping the population of patients with iVF and AF and detecting novel genes associated with iVF and AF. Secondary endpoints are correlation of the presence of gene defects and response to catheter ablation in AF patients and create a better…

A Phase 3, Single-Blind Study to Evaluate the Effect of Eleclazine on Shortening of the QT Interval, Safety, and Tolerability in Subjects with Long QT Syndrome type 3.

The primary objective of this study is to evaluate in subjects with LQT3:- The effect of oral eleclazine on mean daytime QTcF interval (in msec) after 24 weeks of treatment with eleclazine (based on standard 12-lead electrocardiogram [ECG] data)The…

Vascular Ehlers-Danlos syndrome - the COL3A1 gene
A comprehensive natural history study

Primary Objective: Further delineation of the natural history and phenotype/genotype relation of vEDS pateints with a heterozygous pathogenic variant in the COL3A1 gene. Secondary Objectives: 1. reasons for referral for genetic analysis; 2. all…

Unique epigenetic, transcriptional, metabolomic and proteomic characterization of the heart in cardiomyopathy patients

Using epigenetic, transcriptional, metabolomic and proteomic approaches in cardiac and skeletal muscle tissue, we want to reveal distinct biological pathways affected in ACM, DCM and PLN r14del cardiomyopathy.

High intensity interval training in patients with tetralogy of Fallot

Primary Objective: To examine the effect of an online based exercise training protocol on ventriculo-arterial coupling , as assessed by pulse wave velocity and wave reflection patterns in the aorta and pulmonary artery in patients operated for…

CeRebrUm and CardIac protection with Allopurinol in neonates with critical congenital heart disease requiring cardiac surgery with cardiopulmonary bypass

This study has been transitioned to CTIS with ID 2024-513041-37-00 check the CTIS register for the current data. Primary objective of this study is to significantly reduce relevant (moderate/severe) parenchymatous brain injury on postoperative MRI…

Systematic Hospital-based Assessment of Rotterdam*s critically Ill children,
their Neurodevelopment and Growth

The main objective of this longitudinal study is to gain insight into the neurodevelopmental trajectories following neonatal critical illness, from the perinatal period to school-age compared to healthy controls. This insight may lead to the…

Quantifying Electropathology in Paediatric Patients with Congenital Heart Disease:
an intra-operative epicardial mapping study

To quantify the role of different abnormal loading conditions on atrial and ventricular electropathology in paediatric patients with CHD.

Mechanistic insights in mitral valve prolapse and associated left ventricular remodelling: Barlow*s Disease versus Fibroelastic Deficiency

Primary Objective:1) Assess different LV loading mechanisms in Barlow's Disease (BD) versus Fibroelastic deficiency (FED), including transvalvular mitral regurgitant and prolapse volume, both with echocardiography and cardiac magnetic resonance…

Cardiac Imaging in congenital aortic stenosis: unravelling risk factors and predicting clinical outcome

The general aim of this study is to gain knowledge on the impact of ConAoS in adult patients, studying the aortic valve itself, the left ventricle and the aorta. The following primary objective is conducted: to describe the prevalence and pattern of…

Towards optimal management of Marfan Syndrome

The aim is to obtain sufficient data about aortic hemodynamics and motion in MFS patients in different disease stages (e.g. native aorta, after conventional surgery and after PEARS procedure) and while receiving different medical treatments, to…

4D flow hemodynamics in the coronary arteries in adults after arterial switch operation for transpostion of the great arteries

The main objective in this explorative study is to perform 4D flow MRI measurement in the reimplanted coronary arteries in arterial switch patients to give insight into the coronary blood flow patterns and investigate the impact of anatomical high…

Better mechanistic understanding and risk stratification of ventricular arrhythmias through ECGI

Main objectiveTo identify and describe the electrophysiological substrate and triggers in patients with (an increased risk of) VTAs using ECGI, in order to improve understanding of arrhythmic mechanisms and use these for arrhythmia risk…

Assessment of myocardial function, endothelial function and perFUSION in early and advanced disease stages of Hypertrophic CardioMyopathy: FUSION-HCM

In different stages of HCM, to measure the: - Myocardial perfusion- Myocardial function- Volume parameters of the heart- Fibrosis- Function of the small vessels (endothelial (dys)function)- Diastolic function and strain of the heart

A long term extension trial of the Phase III lipid-lowering trials to assess the effect of long term dosing of inclisiran given as subcutaneous injections in subjects with high cardiovascular risk and elevated LDL-C (ORION-8)

The primary objectives are to evaluate:-The effect of inclisiran treatment on the proportion of subjects achieving prespecified low densitylipoprotein cholesterol (LDL-C) targets at end of study (EOS)-The safety and tolerability profile of long term…

A CELL-based platform to study the role of the micRotubule network in pediatric inHeritable arrhYTHMia patients and Improve the effiCacy of drug treatment

Primary objectives: The first aim is to examine the role of microtubule network in electrical conduction, protein localization and function in induced cardiomyocytes from pediatric BrS patients, life threatening ventricular arrhythmia patients and…