161 results
The aim of the proposed randomized controlled trial (RCT) is to determine the effectiveness, and related healthcare costs of a mHealth-based targeted clinical monitoring pathway in GUCH patients. The primary research question is to assess the effect…
1. To identify the patients at risk for aortic aneurysms after PDA closure.We expect to find a decreased distensibility of the aorta in this subgroup of patients which will be examined by MRI. Besides the functional MRI study genetic testing of the…
This study has been transitioned to CTIS with ID 2022-502858-14-00 check the CTIS register for the current data. primary objective:To assess the long-term safety and tolerability of mavacamten in participants with hypertrophic cardiomyopathy (HCM)…
Primary Objective: To assess the effectiveness of a personalized executive functioning training program for 4-6 year old children with severe CHD.Secondary objectives: - To relate training effectiveness to disease and treatment characteristics and…
Primary Objective: To assess the efficacy, expressed by change in peak oxygen consumption obtained with cardiopulmonary exercise testing (CPET), of a HIIT program in patients with an RV-PA conduit.Secondary Objective(s): To determine predictors for…
This study has been transitioned to CTIS with ID 2023-506352-24-00 check the CTIS register for the current data. Primary Objectives: • To assess the efficacy of a 48-week course of mavacamten compared to placebo on patient- reported health status (…
5.1 Study hypothesisThe primary study hypothesis states that oral treatment with itraconazole will reduce the epistaxis severity score (ESS) due to the anti-angiogenic effects of itraconazole.5.2 Research question and primary outcomeWhat is the…
To visualize and quantify areas of dysfunctional flow in the TCPC and within the single ventricle in patients after a Fontan procedure and try to determine a relationship between these quantitative energetic parameters and adverse outcome.
The aim of the study is to test the hypothesis that intermittent intravenous paracetamol administration in children after cardiac surgery will result in a reduction of at least 30% of the cumulative morphine requirement.
Primary Objective: Identification of patient characteristics, echocardiographic measurements and biomarkers that can contribute to a better selection of patients that benefit from percutaneous ASD closure at adult age. Secondary Objectives:-…
The primary objective of this study is to describe the intracardiac anatomy and hemodynamics of DILV patients without Fontan circulation using 4D MRI. Furthermore, the functional status and quality of life of these patients will be assessed and…
The primary objective of this study is to optimize the ultrafast ultrasound flow imaging technique for intra and extra cardiac flow visualization in neonates. The secondary objectives are 1) to compare cardiac output determined using conventional…
The primary objective of the study is to evaluate neurocognitive function with use of Praluent after 96 weeks of treatment versus placebo.
Our primary objective is to investigate cross-sectionally the association between various emerging blood-derived biomarkers and right ventricular (RV) function:defined as tricuspid annular plane systolic excursion (TAPSE) measured with…
The main objective of this study is to find biomarkers for the prognosis of the BAV patients by investigating ECFC and EPC functioning, and to gain knowledge on physiological and pathological processes in patients by investigating molecular…
The objective of the study is to evaluate the effect of physical exercise on exercise capacity, quality of life and serum NT-proBNP levels in adult patients with congenital heart disease.
-To assess autonomic parasympathetic and sympathetic function as well as vascular function in a population of patients with univentricular hearts palliated by the Fontan procedure and compare it with the results in healthy subjects.-To assess the…
The primary objectives of the study are:• To evaluate the effect of 24 weeks treatment with CER-001 on carotid Mean Vessel Wall Area (MVWA) as compared to placebo using 3T magnetic resonance imaging (3T-MRI);• To evaluate the safety and tolerability…
Describe the electrocardiographic changes and areas of late myocardial activation encountered in PLN and PKP2 mutation carriers during ajmaline provocation and the relation of these differences to the development for early stages of arrhythmogenic…
Bicuspid aortic valve disease40 patients will be prospectively signed up by their respective cardiologist for an annual MRI scan in our tertiary clinic. In this single centre cross sectional study, the patients will received a 4D flow analysis. Our…