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Cross-sectional study on determinants of contact dermatitis on the hands of construction workers: etiologic studies and development of a diagnostic tool

Primary objective is to determine the actual occurrence of and risk factors for OCD on the hands of Dutch construction workers.With these new insights into the risk factors for OCD, we aim to develop 1) a new diagnostic tool to be used by…

Epigenetic biomarkers to predict psoriasis disease progression * towards tailored therapy.

Primary Objective: To define a top set of genes that most reliably (r >=0.95) distinguish psoriasis from normal skin. We will define this set from differential methylation genes to indicate potential biomarkers.Secondary Objective(s):…

Parental Attitude towards CL ± P during pregnancy;To evaluate and obtain insight into psychological, social and moral factors in order to improve counseling.

To evaluate and obtain insight into psychological, social and moral factors in thoughts and attitudes of pregnant women and their partners carrying a fetus with an isolated CL ± P in order to improve counseling.

Treacher Collins syndrome: Genectis and OSAS

Primary objectives:1. To analyze the exact pathogenic mutations in the TCOF1 gene in TCS 2. To determine the severity, prevalence, natural course within the cohort TCS patients and potential metabolic and physical effects of OSAS in TCSSecondary…

Genetic susceptibility and skin irritability

Primary Objective: 1) We want to investigate whether carriers of FLG-null mutations show higher responses to exposure to the skin irritant SLS than non-carriers.2) Furthermore, we want to investigate whether carriers of mutations in the genes coding…

Molecular pathology of skin disease

To elucidate the molecular basis of skin disease.

Field testing of a Patient-Reported Outcome Measure for Cleft Lip and Palate:
The CLEFT-Q

To contribute to completion of the psychometric development of the Cleft Q

The skin microbiome in X-linked recessive ichthyosis and autosomal recessive congenital ichthyosis

Primary Objective:Our main objective is to analyse if the microbiota composition of the affected skin is different from the non-affected skin in XRI and ARCI. Secondary Objectives:(1) To investigate the composition of the skin microbiota of patients…

Expression of hSPCA1 and ultrastructural analysis of the skin before and after laser therapy in Hailey-Hailey disease

We aim to (1) study the expression of hSPCA1 in keratinocytes before and after laser therapy and (2) verify the loss of acantholysis by immunohistochemistry and electron microscopy of cell-cell adhesions before and after laser therapy.

The wound care of children with Epidermolysis Bullosa as a source of stress for their parents and themselves.

The overall objective of this study is gaining insight into needs and options for psychological treatment of parents and their children with EB with regard to problems related to wound care.Specific objectives are: 1. To examine coping strategies of…