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Effectiveness of Eye Movement Desensitization and Reprocessing on Post Traumatic Stress Disorder in persons with mild intellectual disability and psychosis: A multiple baseline study

The main purpose of this study is to find out whether EMDR is a safe and effective treatment to reduce the symptoms of PTSD in people with mild intellectual disability and borderline intellectual functioning. In addition, it is expected to reduce…

A study to explore the safety, tolerability, pharmacokinetic profile, and potential efficacy of Guanabenz in patients with early childhood onset Vanishing White Matter (VWM)

To evaluate safety, tolerability pharmacokinetic profile; to explore pharmacodynamics; to evaluate major effects of Guanabenz on quantitative MRI and clinical parameters in pediatric patients with VWM; explore biomarkers in blood and cerebrospinal…

Myotonic Dystrophy, PrOteiN and Diet study. Part 1.

This study aims to assess metabolism in patients with DM1, in resting state, in the normal situation and during exercise, taking into account muscle mass, and compared to healthy age- and gender-matched subjects. We hypothesize that DM1 is…

Safety and feasibility of ultra-high field magnetic resonance imaging in neonates

The primary aim of this study is to investigate the safety and feasibility of ultra-high field magnetic resonance imaging (MRI) of the brain in neonates and to optimize scan protocols.

STXBP1-Encephalopathy: a multifaceted cohort study into the clinical, electroencephalographical and cellular profile of STXBP1-E patients

Primary Objective:To characterize a cohort of STXBP1-encephalopathy patients in a standardized, integrative manner, including in-depth clinical profile characterization and EEG recordings. Moreover, for a subgroup of patients, iPSC-derived induced…

The psychometric properties of the Zuidwester Balans Schaal (ZBS).

The objective is to research the psychometric properties (feasability, reliability and validity) of the Zuidwester Balans Schaal.