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Determination whether the lack of functional AQP2 in kidneys of patients suffering from nephrogenic diabetes insipidus induces cyst formation

Does the lack of the Aquaporin-2 water channel cause cyst formation in patients suffering from nephrogenic diabetes insipidus?

Neurogenic bladder in children: use of feed-back tools during standard treatment with anticholinergics.

We aim to increase patient compliance by extending the existing treatment protocol of (oral or intravesical) anticholinergics plus application of CIC with the addition of bladder pressure measurement performed at home during CIC plus access to an…

'Kidney Team At Home'; Health education on kidney transplantation and the different transplantation options for kidney patients and their family and friends'

The main objective of this research is to contribute to the elimination of disparities in care between Dutch and non-Dutch kidney patients where living donation is concerned. The primary objective is evaluating the effectiveness of an intervention…

Consequences of a congenital monokidney in patients with MCKD

Primary Objective: Mapping the consequences of a congenital monokidney on kidney function for children with MCKD.Secondary Objective(s): - Giving recommendations about follow-up for children treated with nephrectomy for MCKD.- Defining better blood…

A Study of the Prevalence of Apolipoprotein L1(APOL1) Alleles Among Individuals With Proteinuric Kidney Disease Who Are of Recent African Ancestry or Geographic Origin

• Estimate the prevalence of APOL1 genotypes among individuals with FSGS who identify themselves as being of recent African ancestry or geographic origin• Estimate the prevalence of APOL1 genotypes among individuals with other forms of proteinuric…

The DIPAK Observational Cohort Study: a multi-center, longitudinal, observational study to investigate renal disease progression and association of disease biomarkers with renal disease progression and ADPKD-related outcomes.

Overall aim: Given the aforementioned rationale it is therefore important to know the natural course of the disease and stage specific morbidity and mortality factors in a longitudinal observational study, to evaluate the levels of and associations…

Hydrochlorothiazide and metformin cross-over study for attenuating aquaretic side-effects in ADPKD patients treated with tolvaptan

To demonstrate whether hydrochlorothiazide or metformin can diminish aquaresis in patients with ADPKD who are treated with tolvaptan as measured by 24-hour urine volume.

The role of Copeptin as a biomarker of volume status in pediatric polyuric tubulopathies

To investigate copeptin levels in pediatric polyuric tubulopathies such as Nephrogenic Diabetes Insipidus (NDI), Renal Fanconi syndrome and Bartter syndrome to use it as biomarker for the volume state of these patients.

Improving genetic and phenotypic screening of patients with renal tubulopathy-related disorders

In this study, we aim to improve the genetic diagnosis of patients with genetic renal tubulopathy-related disorders. We hypothesize that a higher diagnostic yield can be obtained by genetic re-screening of patients using the updated renal gene panel…