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MRKH syndrome caused by Intrauterine Placental Transfusion between sex-discordant twins?

The aim of this study is to determine whether male microchimerism is present in patients with MRKH syndrome. This would be a sign of intrauterine cell trafficking - and possible AMH transfer- from male to female co-twin. This placental blood…

Sexual functioning in women with the Mayer-Rokitansky-Küster-Hauser syndrome (MRKH syndrome) and their partners and physiological sexual arousal responses in these women with a surgical or non-surgical created neovagina

The study comprises 2 parts.Part 1: Primary: to assess sexual functioning, sexual self image and psychological and relational functioning in MRKH women with surgical or non- surgical created neovaginas and their partners and make a comparison with…

Molecular studies on reduced ovarian reserve and embryo competence in BRCA1/2 mutation carriers

Investigate the association between BRCA1/2-mutations, DNA damage, apoptosis and oocyte/embryo quality in immature germinal vesicle (GV) bearing oocytes, immature metaphase 1 (MI) and unfertilized mature metaphase 2 (MII) oocytes and affected early-…

Sex hormones, sex chromosomes, and sexual differentiation of the brain

Our objective is to determine the role of androgens and the Y-chromosome in sexual differentiation of the brain. Women with CAIS, who only differ from typical women in that they have a Y-chromosome, and from men in that they cannot respond to…

Genetics of pelvic organ prolapse; identification of specific gene defects in patients and their family members.

Genetic analysis of the familial inheritance pattern of the COL3A1 2209G>A polymorphism.

Longterm psychological riskprofiles in women at risk for hereditary breast cancer adhering to surveillance or opting for prophylactic mastectomy

To identify the determinants of psychological vulnerability through time (for the development of the prognostic risk profiles)

Turner syndrome minipuberty study

The hormonal range of LH, FSH, AMH, inhibin B, testosterone and estradiol in girls with TS during the minipuberty and the relation of the hormone serum levels with the karyotype.

Is MRKH syndrome caused by Intrauterine Placental Transfusion between sex-discordant twins?
- measurement of AGD / 2D:4D ratio-

The aim of this study is to assess the relationship between the AGD, the 2D:4D ratio and the presence of MRKH syndrome, endometriosis and PCOS.