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An open-label, multi-center, roll-over study to assess long term safety of lenvatinib monotherapy or lenvatinib combination regimen or comparator treatment arm to cancer patients in Eisai sponsored lenvatinib trials

The primary objective is to assess long-term safety of study drug(s) in subjects who are enrolled in Eisai-sponsored lenvatinib studies.

The Brabant Study: a prospective cohort study among pregnant women

The main objective of the Brabant Study (BS) is to investigate possible different trajectories of thyroid function during pregnancy taking hCG hormone into account. Moreover, we aim to investigate whether pregnancy complications (e.g. pre-eclampsia…

Glucocorticoid Receptor Antagonism in the Treatment of Cushing Syndrome (GRACE): A Phase 3, Double-Blind, Placebo-Controlled, Randomized-Withdrawal Study of the Efficacy and Safety of Relacorilant

Primary • To assess the efficacy of relacorilant for the treatment of endogenous Cushing syndrome based on BP control at Week 12 of the Randomized- Withdrawal (RW) phase compared with placebo• To assess the safety of relacorilant for the treatment…

The effects of sex hormone administration on marrow and visceral adiposity

Primary Objective: To determine the effect of sex hormones on bone marrow fat. and visceral fatSecondary Objective(s): * To determine the effect of sex hormones on visceral and liver fat.* To test whether DXA can be used to calculate the amount of…

The effect of transsphenoidal pituitary adenomectomy on macular ganglion cell thickness, post-illumination pupil response, and sleep-wake rhythm

The primary objective of this study is to determine the effect of transsphenoidal adenomectomy on parameters of macular ganglion cell thickness and the PIPR in patients with optic chiasm compression. The main secondary objective is to assess the…

Determinants and mediating mechanisms of quality of life and disease-specific symptoms among thyroid cancer patients: the WaTCh study

Our main objective is to assess QoL and disease-specific symptoms over time. Our secondary objectives are to identify demographic, environmental, biological, physiological and personality characteristics of TC patients who are at high risk for poor…

An Open-Label Extension Study of Levoketoconazole (2S,4R-ketoconazole) in the
Treatment of Endogenous Cushing*s Syndrome

The objective of this study is to assess long-term safety and efficacy durability of levoketoconazole as chronic treatment for endogenous Cushing*s Syndrome (CS).

Healthy volunteer study for development of ASL MR for perfusion imaging of salivary glands

Primary: to determine normal values and test-retest variation of salivary gland perfusion using ASL in healthy volunteers. Secondary: to test the procedure by measuring possible perfusion differences during stimulated or suppressed salivation.

Radioactive iodine treatment versus hemithyroidectomy in patients with symptomatic benign euthyroid goitre

To compare the effect of radioactive Iodine or hemithyroidectomy on the symptoms and quality of life (QoL) of patients with a benign euthyroid goiter.

Short-term effects of a eucaloric ketogenic diet in acromegaly patients

To assess the efficacy of two weeks eucaloric ketogenic diet on GH and IGF-I levels in acromegaly patients.

Treatment with Recombinant human Interleukin 1 receptor antagonist (Anakinra) in patients with Anaplastic Thyroid Cancer: a proof of concept study

To investigate the efficacy of treatment with human recombinant IL1Ra (rhIL1Ra, Anakinra) in patients with ATC in terms of improved health related quality of life (HRQoL), tumor progression and Overall Survival (OS). Secondary objectives: To…

High-field MRI of the compression of the anterior visual pathway in pituitary adenoma

Primary Objectives: - Assess the feasibility and clinical value of 7T MR to provide a more detailed anatomic description of the anterior visual pathway in NFMA patients compared to conventional MRI. - Assess the feasibility of high-field MRI to…

Turner And Klinefelter Treatment Target study

To explore the relationship between hormone levels and HRQoL in patients with TS and KS.

Prospective, primarily direct comparison of 11C-methionine PET versus
11C-choline PET, and secondary 4D-CT, to explore what PET tracer to use
and in which order to use the functional versus the anatomical imaging
technique in the setting of primary hyperparathyroidism

Prospective, primarily direct comparison of 11C-methionine PET versus 11C-choline PET, and secondary 4D-CT, to explore what PET tracer to use and in which order to use the functional versus the anatomical imaging technique in the setting of primary…