61 results
To determine whether the attenuated salivary cortisol response in children with asthma can be explained by the maintenance use of inhaled cortiocosteroids, the chronic inflammatory disease, or the attenuated exercise capacity.
The aim of this study is to determine whether children between 5-17 years born to women with an autoimmune disorder and prednisone use during pregnancy have chronically elevated cortisol levels compared to children born to women with an autoimmune…
Primary objective:We hypothesize that genetic variability influences mitotane pharmacokinetics. Therefore our aim is to explore the inter-individual differences in genes coding for drug metabolizing enzymes in patients treated with mitotane and to…
To determine the sensitivity and specificity of salivary metanephrines and in patients with PCC/sPGL.
The aim of this study is to determine novel (bio)markers that show a stronger correlation with signs of over- and under-treatment than the conventional adrenal steroid profile in children with CAH.
Objectives: Part 1) To assess the prevalence of PA in general practice (part 1 of this study);Part 2) To describe differences of cardiorenovascular damage in newly diagnosed hypertensive patients with versus without PA (part 2 of this study);Part 3…
The primary aim of this study is to investigate the recovery of the circadian rhythm of the hypothalamic-pituitary-adrenal axis during a glucocorticoid tapering regime. Secondary objectives include the effect of a tapering regime on melatonin rhythm…
To determine the value of multimodality image registration of cone-beam CT (CBCT) and CT in increasing the success rate of adrenal vein sampling procedure compared to procedures without CBCT guidance.
- assessment of age dependent reference values (ages 20 - 70 yrs) for plasma renin (activity and concentration), serum aldosterone and 24h urinary aldosterone (free and metabolites) during a regular diet and after a 3 day oral salt loading test-…
A core part of the scientific efforts of ENS@T researchers bases on the establishment of a common registry and associated collection of biomaterials. Patients with adrenal tumours prospectively included in the ENS@T registry will be asked to provide…
1. Examen if the outcome of the 1 mg Overnight Dexamethasone suppression test is influenced by the use of oral contraception.2. Examen how many weeks after ceasing the use of orale contraception the 1 mg Overnight Dexamethason suppression test is…
Primary objective:to identify new and improved disease biomarkers and establish the biochemical and molecular basis for variations in the clinical presentation of the different groups of tumors.Secondary objectives:• compare the diagnostic utility…
Comparison of the salivary cortisol response after a standardized exercise test between prepubertal heathy children and children with asthma.
Primary objectiveTo compare the efficacy of adjuvant mitotane treatment vs observational follow-up only in prolonging recurrence free survival (RFS) in patients with ACC after complete resection and low-intermediate risk for disease recurrence.…
Here we propose to perform a prospective, randomized, multicenter study that compares effectiveness of AVS with effectiveness of CT-scanning for the diagnosis of PA subtype. There is no criterion standard for accuracy of the diagnosis of PA-subtype…
The objectives of this pilot study are to explore differences in sleep and fatigue, and the relation with the function of the HPA axis, between survivors of childhood ALL and healthy controls.
The objective of the study is to determine whether 11C-metomidate PET can differentiate between BAH and APA./PAH
To answer the following research questions:How is quality of life in patients with adrenal insufficiency?How is cognitive functioning in patients with adrenal insufficiency?Is there a difference in cognitive functioning between patients who did/did…
The main objective of this study is to construct a population-pharmacokinetic model, in order to evaluate the influence of patient characteristics on the pharmacokinetics of mitotane in patients treated with this oral therapy.
Study the mechanisms of BAT activity and the effects of BAT acitivity on energy homeostasis.