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Quantitative and qualitative analysis of cortisol and adrenocorticotrophic hormone (ACTH) secretion in patients with subclinical Cushing syndrome (SCS) and bilaterally enlarged adrenal glands

To investigate cortisol and ACTH rhythm (frequency, amplitude and regularity of cortisol and ACTH secretory pulses) in patients with SCS and bilateral adrenal involvement.

The effect of intermittent sampling on aldosterone lateralisation during adrenal venous sampling (AVS) in patients with primary aldosteronism (PA)

To study the variability of the lateralisation of the aldosterone/cortisol ratio*s when 3 instead of 1 sample is obtained and to study whether instantaneous measurement of cortisol during the procedure will prove to be advantageous.