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Pharmacogenetics of Mitotane

Primary objective:We hypothesize that genetic variability influences mitotane pharmacokinetics. Therefore our aim is to explore the inter-individual differences in genes coding for drug metabolizing enzymes in patients treated with mitotane and to…

Salivary, plasma metanephrines and anxiety levels in pheochromocytomas

To determine the sensitivity and specificity of salivary metanephrines and in patients with PCC/sPGL.

Inhalation or nasal corticosteroids and prevalence of hypothalamic-pituitary-adrenal axis suppression in HIV-infected patients

Primary objective:a. How often do inhalation or nasal corticosteroids lead to suppression of the HPA- axis in HIV-treated patients? Secondary objectives:b. Are other variables associated with the HPA-axis suppression? c. Are cortisol measurements in…

A Phase III study of efficacy, safety and tolerability of Chronocort® compared with standard glucocorticoid replacement therapy in the treatment of congenital adrenal hyperplasia.

The purpose of this research study is to compare the safety and effectiveness of Chronocort® with current glucocorticoid treatment regimens in the treatment of CAH over a 6 month period.