16 results
Primary Objective: To characterize the long-term safety and tolerability of AMG 416 in the treatment of SHPT in subjects with CKD on hemodialysisSecondary Objective: To characterize the long-term efficacy of AMG 416 on intact parathyroid hormone (…
1. To explore the validity and usefulness of Bone Microindentation Technique (BMT) in the assessment of bone quality in patients with osteoporosis and a spectre of bone diseases characterised with (localised) increased bone turnover. 2. To study the…
The primary objective of our study is to investigate the performance of FCH-PET as a second-line imaging modality for localizing hyper-functioning parathyroid gland(s) in patients with biochemically proven PHP for whom surgery is indicated, thereby…
Primary: characterize the long-term safety and tolerability of AMG 416 in the treatment of secondary hyperparathyroidism (SHPT) in subjects with chronic kidney disease (CKD) on hemodialysis.Secondary: to characterize intact parathyroid hormone (iPTH…
The purpose of Part 1 of the study is to investigate how quickly and to what extent KHK7580 is absorbed, distributed, metabolized (broken down) and eliminated from the body (this is called pharmacokinetics). The compound to be administered will be…
1. What are the effects of cinacalcet on clinical and biochemical parameters, including bone turnover markers, in patients with primary hyperparathyroidism due to a MEN-I mutation?2. What are the effects of cinacalcet on bone mineral density and…
To facilitate the localization of a parathyroid adenome during surgery (MIP) with a radioactive iodine 125 (I-125) marker. This marker is placed preoperatively ultrasound guided in the affected parathyroid gland, and can be detected with a gamma…
Aim of our study is to investigate the influence of HPT secondary to moderate-severe vitamin D deficiency and vitamin D replacement on the coagulation and fibrinolysis system
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1. Characterization of patients with persistent and recurrent primary hyperparathyroidism after at least one parathyroidectomy, with removal of at least one pathological parathyroid gland.2. Evaluation of pre-operative localization studies;…
The aim of the RHINO trial is to compare the effect of parathyroidectomy and cinacalcet treatment on quality of life in end-stage renal disease patients with hyperparathyroidism and to evaluate cost-effectiveness. The aim of this pilot study is to…
This study has been transitioned to CTIS with ID 2023-510312-40-00 check the CTIS register for the current data. Main objective- to investigate the effect of alfacalcidol on the treatment of secondary hyperparathyroidism in patients after RYGB…
Primary objective: To validate a disease-specific HRQoL questionnaire i.e., the PHPQoL, in a Dutch cohort.Secondary objective: To determine the effect of surgery, medical treatment or conservative treatment in patients with PHPT within our CCT.
The objective is to assess the impact of hypoparathyroidism on quality of life and the burden of disease.
The aim of this multi-centre study is to confirm the efficiency and safety of a new algorithm for calcium management after total thyroidectomy, primarily based on hypocalcemic symptoms.
Prospective, primarily direct comparison of 11C-methionine PET versus 11C-choline PET, and secondary 4D-CT, to explore what PET tracer to use and in which order to use the functional versus the anatomical imaging technique in the setting of primary…