Search for a trial

A Multicenter single-arm Extension Study to Describe the Long-term Safety
of AMG 416 in the Treatment of Secondary Hyperparathyroidism in Subjects With
Chronic Kidney Disease on Hemodialysis.

Primary: characterize the long-term safety and tolerability of AMG 416 in the treatment of secondary hyperparathyroidism (SHPT) in subjects with chronic kidney disease (CKD) on hemodialysis.Secondary: to characterize intact parathyroid hormone (iPTH…

A single center two part study in healthy adult male subjects to determine the human mass balance and pharmacokinetics of a single oral dose of 14C-KHK75801 (Part 1) and to assess the absolute bioavailability based on the pharmacokinetic parameters of a single intravenous microdose of 14CKHK7580 following a single oral dose of KHK7580 (Part 2)

The purpose of Part 1 of the study is to investigate how quickly and to what extent KHK7580 is absorbed, distributed, metabolized (broken down) and eliminated from the body (this is called pharmacokinetics). The compound to be administered will be…