Search for a trial

A prospective single-centre open label study on the efficacy and safety of 4 weekly pasireotide LAR administration in combination with or without weekly pegvisomant in previously controlled acromegaly subjects with combined treatment of long-acting somatostatin analogs and weekly pegvisomant.

The primary study objective is to assess the proportion of patients who remain within the IGF-I age adjusted normal limits with pasireotide LAR (60 mg) monotherapy, after 24 weeks of treatment.Secondary study objectives are assessment of the…

Short-term Efficacy of Stellate Ganglion Block to reduce Hot Flushes in women

To assess the short-term efficacy of stellate ganglion block on hot flush reduction versus sham procedure

A PHASE 3, RANDOMIZED, OPEN-LABEL, ACTIVE CONTROLLED, MULTICENTER STUDY TO EVALUATE MAINTENANCE OF RESPONSE, SAFETY AND PATIENT REPORTED OUTCOMES IN ACROMEGALY PATIENTS TREATED WITH OCTREOTIDE CAPSULES, AND IN PATIENTS TREATED WITH STANDARD OF CARE PARENTERAL SOMATOSTATIN RECEPTOR LIGANDS WHO PREVIOUSLY TOLERATED AND DEMONSTRATED A BIOCHEMICAL CONTROL ON BOTH TREATMENTS

* To assess maintenance of biochemical control of octreotide capsules compared to parenteral SRLs in patients with acromegaly, who previouslydemonstrated biochemical control on both treatments.* To assess symptomatic response to octreotide capsules…

Influence of exogenous growth hormone administration on circulating levels of Klotho in paediatric patients with isolated growth hormone deficiency.

To assess the impact of treatment with rhGH on circulating Klotho levels in paediatric patients with IGHD.

Randomized, double-blind, placebo-controlled oxytocin trial in children with Prader-Willi syndrome.
Effects on social behaviour.

To evaluate the effects of intranasal oxytocin versus placebo on social behaviour and also on eating behaviour in children with PWS.

A double-blind, randomized study to evaluate plasma prolactin levels in healthy volunteers after single oral doses of lorazepam

Evaluation of the effect of single oral doses of lorazepam on plasma concentration of prolactin

A PROSPECTIVE, INTERNATIONAL, MULTI-CENTRIC, OPEN-LABEL STUDY TO ASSESS THE EFFICACY OF AN EXTENDED INJECTION INTERVAL SCHEDULE OF LANREOTIDE AUTOGEL 120 MG IN ACROMEGALIC SUBJECTS WHO ARE BIOCHEMICALLY CONTROLLED ON THE LONG TERM TREATMENT WITH OCTREOTIDE LAR 10 OR 20 MG

The purpose of this study is to look at the effect of changing from monthly (4 weekly) injections of your usual treatment (octreotide LAR) to less frequent treatment (once every 6 or 8 weeks) with lanreotide Autogel 120 mg injections. The study…

An open-label, multi-center, expanded access study of parireotide s.c. in patients with Cushing's disease (CSOM230B2406) (SEASCAPE)

Primary objective: Safety.Secondary objective: Efficacy.

The development, implementation and evaluation of a Psychosocial Intervention for patients treated for NeuroEndocrine Tumors: the PINET study

Purpose:The main focus of our study is the development, implementation and evaluation of a self-management intervention for patients treated for pituitary adenomas and patients with endocrine diseases in general.

Effect of Growth Hormone replacement therapy on cardiovascular risk factors in adult patients with severe growth hormone deficiency: association with IGF-I concentration

Next to cardiovascular risk factors (main objectives: body composition and lipid profile; secondary objectives: remainder) we investigate the effect of GH treatment on glucose metabolism, physical performance, and neuropsychological functioning of…

Evaluation of Intraoperative and early postoperative Growth Hormone Levels for Transsphenoidal Resection in Acromegaly

Determination of prognostic value of intraoperative growth hormone levels on postoperative curation for acromegaly in patients undergoing transsphenoidal resection of pituitary adenoma.

Assessment of Bone Material Strength by Microindentation in vivo in Patients with Acromegaly

To assess Bone Material Strength (BMS) in patients with acromegaly with fractures and without fractures.

Randomized double blind multi-centre study of the effects on low-dose pegvisomant treatment in acromegalic subjects in whom the IGF1 levels has been normalized by long-acting somatostatin analogues

Primary Study Objective:To assess the efficacy and safety of the co-administration of low-dose pegvisomant (40 mg, administered via subcutaneous injection given once a week) and long-acting somatostatin analogs (administered once monthly) on the…

A prospective trial with ketoconazole and octreotide combination therapy for treatment of Cushing*s disease.

The primary endopoint is to determine whether ketoconazole/octreotide combination therapy, followed by octreotide monotherapy, is an effective treatment for Cushing's disease. Secundary endpoints address the effects of this therapy on bone…

Predictive value of baseline and stimulated serum IGF-1 and IGFBP-3 during a dose-escalation IGF-1 generation test with NutropinAq for the 1 year growth response to growth hormone (GH) therapy in short children with low IGF-1 and a normal GH peak in a provocation test

Primary objective: Assessment of the value of the short-term (2 weeks) response of IGF-I (peak IGF-I SDS) to GH in a dosage of 1.4 mg/m2/day (as part of a dose-escalation IGF-I generation test) in comparison to baseline IGF-I to predict the 1 year…

Predictive diagnostic study on the short-term metabolic effects of recombinant human Growth Hormone treatment in growth hormone deficiency and small for gestational age children.

The primary objective of this study is to assess the relation between the short term metabolic changes after start of rhGH therapy and the long term change in height SDS after one year of treatment. Secondly, we want to assess the effects of GH on…

PHASE IIIb, MULTICENTRE, OPEN-LABEL, SINGLE-ARM, STUDY TO ASSESS THE EFFICACY AND SAFETY OF LANREOTIDE AUTOGEL 120 mg ADMINISTERED EVERY 28 DAYS AS PRIMARY MEDICAL TREATMENT IN ACROMEGALIC PATIENTS WITH MACROADENOMA.

To evaluate the efficacy of Lanreotide Autogel 120 mg when used as primary medical treatment in untreated de novo acromegalic patients with macroadenoma

Diagnose of GH-deficiency: comparing the dietary-protein test with conventional Growth Hormone Stimulation Tests

To investigate if there is a correlation between the peak GH concentrations after ingestion of gelatin protein and the peak GH concentrations after the two standard tests (GHST) in order to discriminate between GHD and non-GHD. To investigate the…

A randomized, double-blind, multicenter, phase III study to evaluate the efficacy and safety of pasireotide LAR in patients with Cushing*s disease

To assess the efficacy and safety of two Pasireotide LAR regimens in CD patients.

Saliva pharmacokinetics of methylphenidate (MPH) following ingestion of immediate and sustained release formulations in children with attention- deficit hyperactivity disorder (ADHD)

Objective: Main objective of this study is to compare the area under the MPH saliva concentration versus time curve (AUC) following ingestion of immediate and sustained release formulations of MPH in children with ADHD. Secondary objectives are: 1.…