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A prospective single-centre open label study on the efficacy and safety of 4 weekly pasireotide LAR administration in combination with or without weekly pegvisomant in previously controlled acromegaly subjects with combined treatment of long-acting somatostatin analogs and weekly pegvisomant.

The primary study objective is to assess the proportion of patients who remain within the IGF-I age adjusted normal limits with pasireotide LAR (60 mg) monotherapy, after 24 weeks of treatment.Secondary study objectives are assessment of the…

A novel genetic cause of congenital central hypothyroidism.

Primary objective1) To study the frequency of mutations in this gene in patients with central hypothyroidism and their first- and second-degree relativesSecondary objective: 2) To determine the clinical, biochemical and radiological consequences of…

Evaluation of Intraoperative and early postoperative Growth Hormone Levels for Transsphenoidal Resection in Acromegaly

Determination of prognostic value of intraoperative growth hormone levels on postoperative curation for acromegaly in patients undergoing transsphenoidal resection of pituitary adenoma.

Comparison of VRS-317, a Long-acting Human Growth Hormone, to Daily rhGH in a Phase 3, Randomized, One-year, Open-label, Multi-center, Non-inferiority Trial in Pre-pubertal Children with Growth Hormone Deficiency.

Primary Objective- Compare the safety and efficacy of subcutaneous somavaratan and daily rhGH during 12 months of treatment.Secondary Objective-Evaluate and compare changes in pharmacodynamic responses (IGF-I, IGF binding protein-3 (IGFBP-3), growth…

Day-night rhythmicity in patients with a nonfunctioning pituitary macroadenoma; a prospective study

Research question:1. Do patients exhibit disturbances of sleep duration or circadian locomotor rhythmicity before surgery? 2. Do these variables change after surgery?

Copeptin as a possible predictor of developing diabetes insipidus following transsphenoidal pituitary surgery

We aim to investigate whether copeptin can be used as an early postoperative marker for development of DI. We will measure copeptin levels in patients just prior to and following transsphenoidal surgery to be able to investigate whether copeptin…

A phase I, double-blind, randomised, placebo-controlled study, in three parts (parts A, B and C) to investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of BIM23B065 administered subcutaneously as single and multiple ascending doses to young healthy male subjects

Objectives:Primary Objective: • To assess the safety and tolerability of single and multiple ascending doses of BIM23B065 when given as a subcutaneous (s.c.) bolus injection in young healthy male subjects.Secondary objectives:• To determine the…

Medical assessment of adverse health outcomes in Dutch childhood cancer survivors; a nationwide project; SKION LATER Q2008 onderzoek:
Growth hormone deficiency in children, after treatment for childhood cancer

• To assess the prevalence of short stature, in combination with an aberrant IGF-1 in combination with IGF-BP3 in the entire cohort of childhood cancer survivors and the therapy related risk factors.• To assess the distribution of IGF-1 and IGF-BP3…

A randomized placebo-controlled study in patients with a Gallium-68 DOTATATE PET/CT positive, clinically non-functioning pituitary macroadenoma (NFMA) of the effect of Lanreotide autosolution on Tumor (adenoma) size

To investigate the efficacy of lanreotide therapy as compared to placebo in patients with NFMA and positive pituitary somatostatin receptor imaging using Gallium-68 DOTATATE PET/CT, on tumor size.

Medical assessment of adverse health outcomes in Dutch childhood cancer survivors; a nationwide project; SKION LATER Q2008 onderzoek:
Adult growth hormone deficiency in childhood cancer survivors

To assess the diagnostic accuracy of total and free IGF-1 concentrations by comparing it to the gold standard for detection of growth hormone deficiency in adults, i.e. the insulin tolerance test, in subgroups of patients at risk for growth hormone…

The role of inflammation in the pathogenesis of cardiovascular morbidity in patients with acromegaly

Primary Objective: To examine comprehensively the role of inflammation in the pathogenesis of CV complications in acromegaly. This will be done by exploring the inflammatory and metabolic profiles of patients with acromegaly and correlating these…

Neonatal reference values for thyroid hormones and validation of dried blood spot measurements in the neonatal period

1. To establish reference intervals for thyroid hormones in plasma at the time of the neonatal screening (day 3-7 of life).2. To establish reference intervals for thyroid hormones in plasma around the 14th day of life.3. To compare the…