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Use of Copeptin Measurement after Arginine Infusion for the Diagnosis of Diabetes Insipidus
- the CARGOx Study

The primary objective of this prospective international multicenter diagnostic study is the comparison of the diagnostic accuracy between copeptin measurement after arginine-stimulation (CAS) and the current best diagnostic test copeptin measurement…

An open-label, single-dose study to evaluate the excretion and metabolism of oral [14C]­-ONO-5788, and absolute bioavailability of oral ONO-5788 in healthy adult male subjects

The purpose of this study is to investigate how quickly and to what extent ONO-5788 is absorbed and how ONO5788 is eliminated from the body. . ONO-5788 will be labelled with 14-Carbon (14C) and is thus radioactive. In this way ONO-5788 can be traced…

Effect of sodium oxybate on brown adipose tissue activity in narcolepsy

Primary objective:1. To assess the effect of SXB treatment on cold-induced BAT volume and activity in narcolepsy type 1 patients.Secondary objectives:1. To assess the effect of SXB treatment on thermoneutral BAT volume and fat fraction, lipoprotein…

An open-label, multi-center, roll-over study to assess long term safety in patients with endogenous Cushing*s syndrome who have completed a prior Novartis-sponsored osilodrostat (LCI699) study and are judged by the investigator to benefit from continued treatment with osilodrostat

To evaluatie the long term safety of treatment with osilodrostat for patients with Cushing Syndrome. In addition to evaluating the proportion of patients with clinical benefit (as assessed by the investigator) and determening frequency, severity and…

Identification of the posterior lobe of the human pituitary gland during surgery using its electrophysiological, neural signature

To record and analyse the electrophysiological properties and differences of the human pituitary gland, i.e. the anterior lobe, posterior lobe and adenoma.

Targeted correction of plasma sodium levels in hospitalized patients with hyponatremia:
a randomized, controlled, parallel-group trial with blinded outcome assessment

The aim of this trial is therefore to determine the effects on mortality and rehospitalization rate of a targeted correction of plasma sodium concentration in addition to current standard care in hospitalized hyponatremic patients.

PRolaCT - three Multicenter Prolactinoma Randomized Clinical Trials

This study aims to investigate if endoscopic trans-sphenoidal prolactinoma resection as a first line treatment (PRolaCT-1), or as an equally valid second line treatment after a short (2-12 months) or long (>12 months) period of pretreatment…

Functional magnetic resonance imaging of human hypothalamic responses to oral glucose ingestion in subjects with obesity before and after lifestyle intervention.

The objective of the study is to determine hypothalamic function in response to oral glucose ingestion in subjects with obesity before and after the start of a combined lifestyle intervention (CLI).

Randomized, controlled growth hormone study in children and adolescents with a Prader-Willi-like phenotype, followed by a two year open-label growth hormone study - effects on body composition, growth, psychosocial development and quality of life

To investigate the effects of GH treatment on body composition, psychosocial development, psychomotor development, growth, glucose metabolism, serum lipids, cognition, behaviour, bone mineral density, quality of life and safety parameters in…