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N- acetylcysteine treatment for skin picking in children and young adults with PWS: A randomized, doubleblind, placebo-controlled, cross-over trial.

To evaluate the effects of N-acetylcysteine (NAC; Fluimucil® in Dutch) on skin picking behaviour in children and young adults with PWS.

The role of inflammation in the pathogenesis of cardiovascular morbidity in patients with acromegaly

Primary Objective: To examine comprehensively the role of inflammation in the pathogenesis of CV complications in acromegaly. This will be done by exploring the inflammatory and metabolic profiles of patients with acromegaly and correlating these…

Short-term effects of a eucaloric ketogenic diet in acromegaly patients

To assess the efficacy of two weeks eucaloric ketogenic diet on GH and IGF-I levels in acromegaly patients.

Congenital central hypothyroidism plusminus ACTH or growth hormone deficiency: etiology and outcome

In this predominantly observational study all patients diagnosed with CH-C in the Netherlands between 1-1-1995 and 1-1-2015 will be traced and the following research questions will be addressed:1) What is the mortality rate associated with early…

Phase IIa, open label, dose ascending study to determine the maximum tolerated dose, safety and tolerability, pharmacokinetics and pharmacodynamics of a single dose of lanreotide PRF in subjects with acromegaly previously treated and controlled with either ocreotide LAR or lanreotide Autogel.

Primary:*To identify the maximum tolerated dose (MTD) and to investigate the pharmacokinetics (PK) of a single dose of lanreotide PRF in subjects with acromegalySecondary:*To investigate the safety and tolerability of a single dose of lanreotide PRF…

High-field MRI of the compression of the anterior visual pathway in pituitary adenoma

Primary Objectives: - Assess the feasibility and clinical value of 7T MR to provide a more detailed anatomic description of the anterior visual pathway in NFMA patients compared to conventional MRI. - Assess the feasibility of high-field MRI to…

A new dietary intervention for children with hypothalamic obesity after treatment for a craniopharyngioma: a pilot-study

This pilot-study is designed to assess the feasibility and efficacy of a new dietary intervention (Happy Weight Dotsplan) and therefore to learn if it might be effective on a broad scale with the inclusion of a larger cohort nationwide. We will…

The Efficacy of TRH in Intensive Care patients; a dose finding study

To determine the minimal dose of protirelin that is effective and safe to normalize plasma thyroid hormone levels in patients with prolonged critical illness.

Neonatal reference values for thyroid hormones and validation of dried blood spot measurements in the neonatal period

1. To establish reference intervals for thyroid hormones in plasma at the time of the neonatal screening (day 3-7 of life).2. To establish reference intervals for thyroid hormones in plasma around the 14th day of life.3. To compare the…

The EndoWatch: a smart wearable that serves as *external hypothalamus*

The aim of this study is to determine whether this smart wristband can actually support patients and their parents in managing the consequences of hypothalamic dysfunction. We will investigate what kind of support patients, parents, or caregivers…