66 results
Primary Objectives- To determine the optimal dose of the VEGF-A targeting NIRF tracer bevacizumab-IRDye800CW for an adequate tumor-to-background ratio (TBR) in PTC/FTC/HTC/PDTC lymph node metastases.Secondary Objectives- To evaluate the feasibility…
This study has been transitioned to CTIS with ID 2024-516123-13-00 check the CTIS register for the current data. Part I:Primary Objective: Evaluate the effects of tiratricol on neurodevelopment in young MCT8 deficiency patients, as measured by the…
The primary objective is to assess long-term safety of study drug(s) in subjects who are enrolled in Eisai-sponsored lenvatinib studies.
The main objective of the Brabant Study (BS) is to investigate possible different trajectories of thyroid function during pregnancy taking hCG hormone into account. Moreover, we aim to investigate whether pregnancy complications (e.g. pre-eclampsia…
Primary objective: 1. To compare the difference in thyroid uptake of a low tracer dose radioactive iodine (10 MBq 123I or 37 MBq 123I) (1a), in DTC patients after thyroidectomy, before and after a LID of 7 days (1b).Primary objective described in…
Primary aim1) To investigate what proportion of levothyroxine users aged 60 years and older can withdraw from levothyroxine treatment successfully, defined as having normal fT4 levels and TSH levels <10 mU/L at 52 weeks after start of the…
This study has been transitioned to CTIS with ID 2024-515602-34-01 check the CTIS register for the current data. To assess which treatment leads to the best patient outcome on the short term (1 year) and the long term (5 years)
Primary objective: To assess and compare the difference in thyroid gland secretion capacity by measuring maximal FT4 and FT3 response upon intramuscular administration of 0.9mg Thyrogen assessed by AUC0-48hours in SCT subjects and healthy controls.…
Primary Objective: The aim of this pilot study is to determine the willingness of patients to participate in a RCT regarding de-escalation of treatment of PTC and to observe adherence to this less aggressive approach. This will be accomplished by…
Our main objective is to assess QoL and disease-specific symptoms over time. Our secondary objectives are to identify demographic, environmental, biological, physiological and personality characteristics of TC patients who are at high risk for poor…
The main objective of the research is to differentiate between benign and malignant thyroid nodules using the GC-IMS for the analysis of breath, urine and blood in a (multicenter) study and reduce the amount of unnecessary surgery.
Primary Objective:To investigate whether there is a difference in the number of participants that will reach optimal LT4 supplementation (i.e. stability of TSH levels and symptoms) in the breakfast group compared to the fasting group.Secondary…
The aim of this study is to identify whether we can improve laboratory diagnostics in patients with hypothyroidism receiving thyroid hormone supplementation. We will investigate whether, in addition to the current laboratory tests of TSH and fT4,…
Therefore, this feasibility study will evaluate whether the 18F-PSMA PET/CT is capable of MTC lesion detection. Moreover, we will compare its ability to detect MTC lesions with a routinely used PET scan, the 18F-FDG PET. By exploring new tracers in…
2.1 Primary Objective- To determine the optimal dose of the c-Met targeting NIRF tracer EMI-137 for an adequate tumor-to-background ratio (TBR) in PTC lymph node metastases.2.2 Secondary Objectives- To obtain information on safety aspects of…
Primary objective: - obtain an comparison in diagnostic results of two methods of ultrasound assisted fine needle aspiration biopsies (FNAB) of the thyroidal gland in the Jeroen Bosch hospital (JBZ).Secondary objective:- can the cytological thyroid…
This prospective evaluation of the dynamics of thyroid hormones during cancer treatment in children is designed to determine the prevalence of thyroid hormone deficits at diagnosis, during and directly after treatment and to study changes in thyroid…
To assess the prevalence of hypothyroidism and hyperthyroidism in the entire cohort of childhood cancer survivors and the therapy related risk factors. Specifically:Part I: 1. To systematically review existing studies on the association between…
Primary Objectives 1. Evaluate whether the incidence of caries increases after radioiodine treatment as compared to the pre I131-therapy period in patients with differentiated thyroid carcinoma.Secondary Objectives 1. Evaluate whether the cumulative…
To compare the effect of radioactive Iodine or hemithyroidectomy on the symptoms and quality of life (QoL) of patients with a benign euthyroid goiter.