947 results
In patients with NSTEMI we aim to: 1) compare coronary vulnerable plaque detection between 18F-NaF-PET-CMR and invasive coronary angiography, 2) investigate the relation of coronary vulnerable plaques using 18F-NaF-PET with myocardial infarction…
To investigate the association between shear stress and plaque growth and plaque composition changes over time. Furthermore, it will be investigated how these plaque changes influence the local wall stress.
2.1 Primary objectiveTo determine patterns of response in the transvalvular pressure gradient while altering transvalvular flow.2.2 Secondary objectives-To quantify any added value or differentiation from stress assessment of aortic stenosis…
1. To investigate non-invasive 4D flow CMR for the assessment of aortic arch stenosis and compare and correlate this to conventional imaging modalities and to three-dimensional rotational angiography (3DRA) with computational fluid dynamics (CFD). 2…
This study aims at establishing the influence of sampling site on the variability of ACT measurement at the end of coronary angiography or PCI.
Zie document PROTOCOL SYNOPSIS ABC study
Describe the relation between patterns in biomarkers of vascular inflammation, plaque instability and hypercoagulability and the incidence of recurrent ACS
Primary objectives: to investigate functional and histopathological changes of the right ventricle before and after PVR and PPVI. To investigate if non-invasive assessment of RV-remodeling using CMR T1 mapping and T1rho mapping is possible and to…
Primary Objective: To compare the effects of hypothyroidism and hyperthyroidism on cardiac left ventricular function, as assessed by CMR, in subjects with differentiated thyroid cancer during their early treatment.Secondary Objective(s): To compare…
In the present study we aim to determine the value of microvascular resistance measurements in the acute setting to predict the occurrence of MVO in the following days, using the combined pressure-flow wire. Therefore patients with an acute MI will…
Primary objective: To investigate left ventricular diastolic function in AS-patients compared with osteoarthritis patients. Secondary objectives: To assess the prevalence of valvular heart diseases and conduction disturbances. To assess left…
Primary objective: To validate the quantification of AR by time-densitometry on contrast aortography with the gold standard of CMRI measurements in order to refine the interpretation and evaluate the accuracy of the qRA method. Secondary objective:…
Primary:2. To investigate the prevalence of vulnerable plaques, i.e. plaques with intraplaque hemorrhage on MRI, in individuals with type 2 diabetes, impaired and normal glucose tolerance and a minimal plaque thickness of 2mm on ultrasonography. To…
The current randomized study aims to evaluate potential differences between the Edwards SAPIEN bioprosthesis and the Medtronic CoreValve® system with main focus on periprosthetic aortic regurgitation and additional focus on other clinical and…
The primary objective of this study is to investigate whether circulating fibrotic biomarkers are related to the amount of cardiac fibrosis as determined by MRI in patients. Secondarily, this study aims to investigate whether these biomarkers are…
Primary objectivesTo show that a model incorporating the novel predictors BSPM, TE-ECG and SNPs is superior to existing models in predicting maintenance of sinus rhythm after successful DCC in patients with persistent AF.Secondary objectivesTo…
The main objective of this study is to assess the effect of an acute cardiovascular event on the local and the systemic inflammatory state in humans with AMI as well as the reversibility of these effects after 3 months.
Primary Objectives:- Determine the effect of pulmonary vasodilatation on indexed cardiac output during simulated exercise.- Characterization of structural properties of small pulmonary arteries.Secondary Objectives: - Investigate the effect of…
Compare hemodynamic parameters and flow patterns of the stented Mitroflow bioprosthesis, stentless Freedom SOLO bioprosthesis,transcatheter Edwards Sapien bioprosthesis and healthy control subjects, measured with 4D flow MRI.
To answer the following research questions: 1. Do intimal arterial calcification and medial arterial calcification in the lower extremity arteries increase the occurrence of cardiovascular disease in people with a high risk of cardiovascular disease…