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Imaging and Modeling to investigate the mutual relationship of Plaque growth and biomechanical parameters in human coronary arteries

To investigate the association between shear stress and plaque growth and plaque composition changes over time. Furthermore, it will be investigated how these plaque changes influence the local wall stress.

Aortic Stenosis * Identification of high-risk valve pathology using STRESS physiology (AoS-STRESS)

2.1 Primary objectiveTo determine patterns of response in the transvalvular pressure gradient while altering transvalvular flow.2.2 Secondary objectives-To quantify any added value or differentiation from stress assessment of aortic stenosis…

Four-dimensional flow cardiac magnetic resonance imaging for the assessment of coarctation of the aorta, a monocenter, prospective, diagnostic cross-sectional study.

1. To investigate non-invasive 4D flow CMR for the assessment of aortic arch stenosis and compare and correlate this to conventional imaging modalities and to three-dimensional rotational angiography (3DRA) with computational fluid dynamics (CFD). 2…

Measuring the Activated Clotting Time in patients receiving unfractionated heparin prior to coronary angiography and intervention. A single-centre validation study comparing different blood sampling sites

This study aims at establishing the influence of sampling site on the variability of ACT measurement at the end of coronary angiography or PCI.

Arterial stiffness, Blood Pressure and Cardiac output study; ABC-study;A Prospective, Multidisciplinary study of arterial stiffness measures in patients treated for aortic aneurysms in relation to blood pressure and cardiac output

Zie document PROTOCOL SYNOPSIS ABC study

Preventing contrAst induced Nephropathy after TranscathEter aortic valve Replacement

To evaluate the efficacy of 250ml 1.4% sodium bicarbonate versus hypotone saline hydration prior to TAVI in patients with CKD to prevent CIN.

Right ventricle remodeling after pulmonary valve replacement and percutaneous pulmonary valve insertion, a functional and histopathological assessment.

Primary objectives: to investigate functional and histopathological changes of the right ventricle before and after PVR and PPVI. To investigate if non-invasive assessment of RV-remodeling using CMR T1 mapping and T1rho mapping is possible and to…

Cost-effectiveness of a lifestyle intervention on health and sustainable employability among workers of 40 years and older with high physical work demands: a randomized controlled trial

- to evaluate (cost-) effectiveness of a personalized health intervention among workers of 40 years and older with high physical work demands to contribute to a reduction in CVD and sustainable employability.

Pressure-Flow Measurements Directly after Primary PCI to Predict Late Occurrence of Microvascular Obstruction

In the present study we aim to determine the value of microvascular resistance measurements in the acute setting to predict the occurrence of MVO in the following days, using the combined pressure-flow wire. Therefore patients with an acute MI will…

Calibration of time-densitometry for the quantification of aortic regurgitation

Primary objective: To validate the quantification of AR by time-densitometry on contrast aortography with the gold standard of CMRI measurements in order to refine the interpretation and evaluate the accuracy of the qRA method. Secondary objective:…

Edwards SAPIEN periprosthetic leakage evaluation versus Medtronic CoreValve in tranfemoral aortic valve implantation: the ELECT trial

The current randomized study aims to evaluate potential differences between the Edwards SAPIEN bioprosthesis and the Medtronic CoreValve® system with main focus on periprosthetic aortic regurgitation and additional focus on other clinical and…

Perioperative Transfusion Study (PETS): does a liberal transfusion protocol improve outcome in high-risk cardiovascular patients undergoing non-cardiac surgery?

The primary objective of this study is to assess whether a liberal (6.5 mmol/l) transfusion strategy compared to a restrictive (6.0 mmol/l) transfusion strategy lowers the incidence of major adverse cardiac events (MACE). MACE is defined as a…

The effect of resveratrol on metabolism and cardiovascular risk profile in patients with chronic obstructive pulmonary disease (COPD)

The overall objective is to investigate the efficacy of resveratrol in modulating metabolism and CVD risk profile in patients with COPD. The primary objective is to investigate the effect of resveratrol on CRP as clinical marker of low grade…

Detection of cardiac fibrosis by LGE MRI and circulating biomarkers in patients with myocardial infarction.

The primary objective of this study is to investigate whether circulating fibrotic biomarkers are related to the amount of cardiac fibrosis as determined by MRI in patients. Secondarily, this study aims to investigate whether these biomarkers are…

Multimodality prediction of success of atrial fibrillation rhythm control strategy.

Primary objectivesTo show that a model incorporating the novel predictors BSPM, TE-ECG and SNPs is superior to existing models in predicting maintenance of sinus rhythm after successful DCC in patients with persistent AF.Secondary objectivesTo…

Comparison between stented, stentless and transcatheter aortic valve bioprostheses using 4D flow magnetic resonance imaging

Compare hemodynamic parameters and flow patterns of the stented Mitroflow bioprosthesis, stentless Freedom SOLO bioprosthesis,transcatheter Edwards Sapien bioprosthesis and healthy control subjects, measured with 4D flow MRI.

Coronary CT Angiography for Improved Assessment of Suspected Acute Coronary Syndrome with Inconclusive Diagnostic Work-up

To determine whether CCTA can provide a more efficient diagnostic work-up in suspected NSTE-ACS patients with an initial inconclusive work-up by identifying patients that do not have significant coronary artery disease.

Bioprofiling response to mineralocorticoid receptor antagonists for the prevention of heart failure. A proof of concept clinical trial within the EU FP 7 *HOMAGE* programme « Heart OMics in AGing

Main objective: To investigate whether spironolactone can favourably alter extra-cellular matrix remodelling, assessed by changes in the fibrosis biomarker Procollagen Type III N-Terminal Peptide (PIIINP), in patients at increased risk of developing…

A Randomized, Double-blind, Event-driven, Multicenter Study Comparing the Efficacy and Safety of Oral Rivaroxaban with Placebo for Reducing the Risk of Death, Myocardial Infarction or Stroke in Subjects with Chronic Heart Failure and Significant Coronary Artery Disease Following a Hospitalization for Exacerbation of Heart Failure

The primary objective is to demonstrate that rivaroxaban is superior to placebo in subjects with chronic HF and significant CAD, who are receiving standard care, in reducing the risk of the composite of ACM, MI, or stroke following a recent…

Noninvasive Imaging of Vulnerable Inflammatory Coronary Plaque using Cardiac PET/CT in Humans: a feasibility study

The objective is to study the feasibility of different PET tracers to detect vulnerable plaques in patients with a recent acute coronary syndrome and co-localize these inflammatory lesions with anatomical plaque features obtained with CT based…