412 results
To assess, by use of MRI measurements during exercise, the level of restoration of cardiac function, and to study whether excercise limitation in CTEPH patients after a hemodynamically succesful PEA is caused by an impaired RV stroke volume response…
1. IS there an effect of short-time combined use of NSAIDs and diuretics/RAAS-inhibitors on the heart- and kidneyfunction in orthopaedic patiënts who undergo a total knee- or hipreplacement.2. Is cystatin C a better endogenous marker of kidney…
The objectives of this study are (1) to determine the contribution of psychological factors in the prediction of prognosis, health care utilization, and quality of life (2) to identify biological and psychological mechanisms that can explain the…
The first objective of the study is to predict the prevalence of PH in sarcoidosis with pulmonary involvement, and to optimize the diagnostic approach in screening for PH associated sarcoidosis using the RHC as gold standard (Galie, 2009). The…
Primary Objectives:• To evaluate the efficacy of intravenous (IV) FCM compared to usual care on exercise capacity.Secondary Objectives:• To evaluate the efficacy of IV FCM compared to usual care on biomarkers for iron deficiency (ID), cardiac…
The purpose of this trial is to evaluate the long-term effects and cost-effectiveness of adaptive servo-ventilation (ASV) on the mortality and morbidity of patients with stable heart failure due to left ventricular systolic dysfunction, already…
1. To predict the clinical course (in terms of occurrence of ALI and ARDS, duration of mechanical ventilation, need for renal replacement therapy, length of ICU-stay, length of hospital-stay, ICU-mortality, 30-day mortality) in patients after…
To predict the influence of PEEP on Pms and eH.
The main objective of the current study is to evaluate which patients in the twilight zone of PH will benefit from PAH specific therapy. We will assess the (early) response to PAH specific treatment and determine potential predictors of adverse…
The primary objective of this study is to continue to evaluate the safety and tolerability of LCZ696 in heart failure patients from PARADIGM-HF receiving open-label investigational drug.There are no secondary objectives for this study.
Do healthy adult males, age 4-70 years without cardio- or pulmonary disease reach a higher maximum oxygen uptake at cardiopulmonary exercisetest with the ramp-protocol in comparison to the standard bloc-protocol? P: healthy adult man, age 40 en 70…
The main objective of this study is to develop a new screening method for CSA in CHF patients, combining adjusted questionnaires, overnight pulse oximetry, the Snore Detector Pro app and the so-called Zzzx app.
Adding PCT measurements to standard diagnostics to support decision making regarding initiation of antibiotics. To evaluate an advantage of PCT guided prescription of antibiotic treatment over established treatment practice with respect to 90-day…
The purpose of the study is to examine how the Minicare I-20 fits into the ambulance workflow. Relevant process data of the ambulance workflow was collected (stage 1) looking specifically into chest pain patients. This second stage will focus on…
The primary objective of this study is to demonstrate that individually optimized, triple-site biventricular pacing is superior to standard biventricular pacing in reversing ventricular modeling as demonstrated by Echo Left Ventricle End-Systolic…
Therefore, the aim of our study is to determine whether and when changes in sympathetic signalling in the RV of IPAH patients occur, using [11C]-HED and [11C]-CGP-12177 PET imaging.
To evaluate the safety and performance of MANTA in achieving hemostasis in femoral arterial access sites in patients undergoing percutaneous transcatheter interventional procedures using a 10-18F procedure sheath for purposes of obtaining a CE Mark…
In a pilot study patients scheduled for a regular implantation of a (or undergoing an upgrade to a) CRT-device will also be implanted with a heart monitor in the pulmonary artery. This implantable heart monitor (IHM) will collect data during…
Compare the hemodynamic response to pelvic and conventional LBNP and assess head motion.
We aim to study the role of PVAT in regulation of vascular function, tissue perfusion and glucose uptake in muscle. We hypothesize that PVAT determines insulin-induced vasoreactivity when studied ex vivo and correlates with insulin-induced…