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The role of perivascular adipose tissue in the regulation of insulin sensitivity through muscle microvascular recruitment in individuals with obesity or type 2 diabetes before and after bariatric surgery.

We aim to study the role of PVAT in regulation of vascular function, tissue perfusion and glucose uptake in muscle. We hypothesize that PVAT determines insulin-induced vasoreactivity when studied ex vivo and correlates with insulin-induced…

Impact of arterio-venous fistulas on cardiac contractility in hemodialysis patients evaluated using cardiac magnetic resonance derived functional and geometrical parameters

To perform a detailed non-invasive analysis of mechanical activation under different volume loading conditions and to describe the accompanying hemodynamic response.

Single-center, open-label study in healthy male subjects to evaluate the absolute bioavailability of a 10 mg oral dose of vericiguat (BAY 1021189) (as IR tablets following a high-fat, high-calorie meal) in comparison to an intravenous, 14C-labeled micro-dose (20 µg) of vericiguat

The primary objective of this study is to evaluate the absolute bioavailability of an oral dose of 10 mg vericiguat (BAY 1021189) given as two 5 mg IR tablets following a high-fat, high calorie meal in comparison to a 14C labeled micro dose of…

Cardiac Contractility Modulation (CCM) Therapy in Subjects with Medically Refractory Heart Failure: A Randomized Efficacy Study (*IMPULSE-HF*)

The study is designed to substantiate the efficacy of CCM in the heart failure population with ejection fraction ranging between 25 and 45%. The study is designed in an adaptive manner to ensure proper statistical significance and power of the…

Heart failure and Promotion of Physical Activity before and after Cardiac reHabilitation

To investigate in our defined HF patient population if monitoring in combination with motivation on physical activity leads to an increase in enrollment rate for cardiac rehabilitation and sustained physical activity after cardiac rehabilitation as…

Sulodexide for chronic heart failure: a proof of concept, randomized, open-label, placebo-controlled study

To assess the efficacy of treatment with sulodexide for chronic heart failure.

Induced pluripotent stem cell-derived 3D models to unravel the phenotypic diversity of arrhythmogenic cardiomyopathy

Our main objective is to investigate whether the diversity between identical mutations is merely caused by environmental factors, or whether genetic factors also underlie the manifestation of the disease. With this study, we aim to use ACM patient-…

LV flow patterns in systolic heart failure: A new aspect elucidated by high-frame rate echocardiography (PHRAsE study)

This will be a prospective and observational study.Primary Objective: * To explore the value of LV flow pattern with high-frame rate echocardiography in patients with systolic heart failure and relate the flow patterns to CRT response.* To assess if…

Pancreatic exocrine insufficiency in heart failure

Primary Objective: The primary objective of this study is to investigate the prevalence EPI in the advanced HF population Secondary Objectives: • To determine the association between exocrine pancreatic function and markers of HF• To determine the…

A Non-Interventional Mechanistic Study to Characterize Biomarkers for Mitochondrial Dysfunction and Inflammation in Subjects with Mitochondrial Disorder and Cardiomyopathy, and Healthy Volunteers

To explore, whether markers of mitochondrial dysfunction measured in isolated PBMCs or immune cell subpopulations differ between subjects with mitochondrial disorders and cardiomyopathy and healthy volunteers.

MAnagement of high bleeding risk patients post bioresorbable polymer coated STEnt implantation with an abbReviated versus prolonged DAPT regimen

The objective is to compare, within current guidelines (GL) and instructions for use (IFU), an abbreviated versus a prolonged DAPT duration after bioresorbable polymer coated Ultimaster sirolimus-eluting stent implantation in patients presenting HBR…

JBZ Atellica VTLi BNP,NT-proBNP en D-Dimeer sample comparison study

Primary objective of the study is to compare the readings of the different sample types (venous whole blood, plasma and capillary) for the three different analytes (BNP / NT-proBNP / D-dimer) on the Atellica VTLi system, according to CLSI EP09c…

RCT Extended and Comprehensive E-health Modalities to Improve OutcomE in Patients with WorseneD Heart Failure (EXCEED-HF)

The primary objective is to demonstrate efficacy of an extended remote monitoring intervention, including a TM app, HF nurse guided home care and multidisciplinary network collaboration using the Virtual Ward platform, on top of standard HF care…

Cardionomic Cardiac Pulmonary Nerve Stimulation Pilot Study

The objective of the study is to assess the safety and performance of the Cardionomic cardiopulmonary nerve stimulation (CPNS) system in patients with acute decompensated heart failure. The intent of the study is descriptive in nature, without a…

effect of a higher bloodpressure on Right Ventricular Function

To demonstrate differences in RV function by raising the systemic blood pressure with norepinephrine.

Randomized controlled trial to compare the effects of single versus repeated intracoronary application of autologous bone marrow-derived mononuclear cells on total and SHFM-predicted mortality in patients with chronic post-infarction heart failure;REpetitive Progenitor cEll therapy in Advanced chronic hearT failure (REPEAT trial)

The current randomized controlled trial should investigatewhether- 2 sequential intracoronary BM-MNC applications are associated with a lower mortality than oneintracoronary BM-MNC application- 2 intracoronary treatments with BM-MNC are associated…

ECG Belt for CRT Response

The purpose is to compare ECG Belt Research System managed cardiac resynchronization therapy (CRT) patients and a control CRT group with respect to left ventricular (LV) remodeling..

HELIOS-A: A Phase 3 Global, Randomized, Open-label Study to Evaluate the Efficacy and Safety of ALN-TTRSC02 in Patients with Hereditary Transthyretin Amyloidosis (hATTR Amyloidosis)

This study has been transitioned to CTIS with ID 2023-508365-33-00 check the CTIS register for the current data. To determine the efficacy of ALNTTRSC02 in patients with hATTR amyloidosis by evaluating the effect on neurologic impairment. To…

ON-SCENE Initiation of Extracorporeal CardioPulmonary Resuscitation During Refractory Out-of-Hospital Cardiac Arrest

In this study, we aim to improve survival to hospital discharge and costs/QALY in young patients with OHCA by decreasing the time in cardiac arrest by initiating ECPR on scene.

Hemodynamic Monitoring with the CardioMEMS PA sensor and Quality of Life in Patients with Chronic Heart Failure: The MONITOR HF Trial

We hypothesize that the CardioMEMS HF system will be safe and superior to standard care in improving the quality of life and health status in patients with chronic HF in the Netherlands. Additionally, we hypothesize the CardioMEMS HF system is cost-…