412 results
AdOpt CRT is designed to compare indices of cardiac function at device settings optimized using an investigational Adaptive CRT (aCRT)algorithm versus CRT with nominal programming. The comparison will be performed during rest and submaximal exercise…
To assess changes in left ventricular performance using echocardiography as well as ventricular remodelling, changes in sleep and changes in mood, anxiety and cognitive functions occurring as a result of treatment of predominant central sleep apnoea…
Early detection and prediction of cardiotoxicity in chemotherapy-treated patients with the use of the new high sensitivity troponin t assay.
The primary objective of the study is to relate depression and anxiety in CHF patients receiving an ICD to the occurrence of ventricular tachyarrhythmias. Secondary objectives of the study are:Assessment of the effects of depression and anxiety on…
We aim to investigate thirst in the above mentioned patient groups, applying a Visual Analogue Scale (VAS) and, where ethically acceptable, a new thirst provocation test which we will develop in a group of healthy probands. Using these tools, we aim…
We would like to evaluate the beneficial effects of fibrate treatment on muscle mitochondrial and cardiac function in patients with NLSDM.
Primary Objective:• To investigate the relationship between ID, VB12D or FD and outcome (HF hospitalization and all-cause mortality) in patients with chronic HF. Secondary Objectives:• To investigate the prevalence of ID, VB12D or FD in chronic HF…
The main objective of this pilot study is to determine the effects of vascular access construction on autonomic and cardiac function.
The primary objective is to continue to assess the long term safety of the CardioKinetix Parachute Implant System in the partitioning of the leftventricle in patients with heart failure due to ischemic heart disease.
To describe the pharmacokinetic profile of a 24 hour infusion of levosimendan and its active metabolites in children with acute or chronic heart failure.
BAY 63 2521 is a stimulator of the soluble guanylate cyclase (sGC) and is intended for the treatment of cardiovascular diseases, especially pulmonary hypertension (PH).To assess the longterm safety and tolerability of oral BAY 63-2521 in patients…
The main objectives of this study are to evaluate the effects of HIT in CHF patients on cardiac output at rest assessed with cardiac magnetic resonance imaging(cMRI), and to investigate the relation between changes in resting cardiac output and…
Our research group recently found that almost 50% of all OHCA patients develop hyperfibrinolysis, and found an interesting association between the degree of hyperfibrinolysis and hypoperfusion. Hypoperfusion was determined by base excess (BE),…
To examine the impact of heart failure on the change in endothelial function in response to ischaemia reperfusion injury. A secondary objective is to explore the ability of ischaemic preconditioning to protect against the decrease in endothelial…
Objective: To determine the (added) value of molecular imaging techniques for selecting patients that will benefit from CRT.
To compare the effects of central versus peripheral drug administration on the rate of return of organised electrical activity and/or spontaneous circulation during CPR.
PrimaryThe objective of the study is to investigate the safety and tolerability of the partial adenosine A1 agonist BAY 1067197 on top of standard therapy in patients with chronic systolic heart failure.SecundaryPharmacodynamische en hemodynamische…
At the moment CA can only be assessed in laboratories that have been set-up to perform the specific measurements. This study tries to use a diversity of methods for measuring and analyzing CA and reach a method that is a simplified version of…
The primary aim of this project is to examine the impact of heart failure on functional sympatholysis. The second aim of this study is to examine whether nitrate supplementation can improve the effects of functional sympatholysis in heart failure.
The purpose of this clinical trial is to evaluate the post-implant safety and efficacy of the Medtronic Attain Performa Quadripolar Model 4298, Model 4398, and Model 4598 Left Ventricular (LV) leads (*Attain Performa leads*) and also assess and…