412 results
The primary objective is to evaluate the safety and efficacy of the PulseCath during support of patients with impaired ventricular function, for a period between 24 hours minimum and 14 days maximum. Safety will be assessed by the incidence of…
Study on the validity and usability of myBLOxs portbale centrifuge at home by patient with heartfailure. Validity is measured by comparing laboratory results from venous plasma with those from capillary plasma.
The main objective is to investigate mechanical alternans and MTWA in patients with heart failure caused by coronary artery disease to demonstrate a possible correlation between these two phenomena.
The aim of the present study is to investigate whether the relation between QRS vector, interventricular asynchrony and improvement in LV pump function is present in CRT patients. Subsequently, we want to show that the QRS vector can be used as a…
Primary:To examine changes in health status (functional status and quality of life) and emotional distress (i.e. anxiety and depression) over time in patients following LVAD implantation, focusing on intra-individual changes, with a view to…
Primary Objective: Improvement in myocardial blood flow and reverse remodelingSecondary Objective(s): Improvement in wall motion abnormalities, left ventricular function and NYHA class
Primary:To investigate the effect of VLCD (very low calorie diet) in obese patients with type 2 DM and cardiovascular complications on cardiac function, pulse wave velocity and myocardial triglyceride contentSecondary:To investigate the effect of…
-Determination of the effects of an exercise program on ectopic fat accumulation in heart, liver and skeletal muscle-To assess the relationship between metabolic and inflammatory parameters with changes in MRI outcome-To assess the differences in…
The primary purposes of this study is to characterize the optimal electrode placement and electrode spacing on the lead*s spiral fixation such that at least one electrode on the spiral will contact the myocardium site in the coronary vein. Secondary…
The aim of this study is to identify direct markers of muscle and adipose tissue hypoxia in COPD and CHF patients in relation to the altered muscle oxidative phenotype and the putative mediators HIF-1α and PPARs/PGC-1. Insight in the underlying…
The primary goal is investigate the method to achieve the most effective clearance od midmoecules in the first 6 hours of HVHF.The secondary goal is to determine to wich proportion the clearance of midmolecules due to proteinprecipitation declines…
Aim is to establish the relation between plasma and tissue AGE levels and the severity of diastolic/vascular dysfunction and its relation with symptoms in patients with type 2 DM with and without CHF, and in patients with CHF without DM. Primary…
We aim to investigate which part of the pulmonary vasculature, the obstructed or non-obstructed, is responsible for the pulmonary vasodilator response.
To investigate a developed methode to diagnose heart failure accurately in nursing home residents. The developed method have to be workable, should lay the foundation for further research and should lead to a first indication for the prevalence of…
Can mobile echocardiographic and pulmonary function measurements be performed adequately and patient-friendly within 24 hours after admission to hospital and before discharge in COPD patients aged 65 years or over with an exacerbation?
1. To study the rate of change of diastolic and systolic LV function and LV structure, and the incidence of heart failure over a 7-year period in subjects with and without DM2 2. To study the potential determinants of accelerated deterioration of LV…
The study investigates the role of the RV efficiency in the deterioration of RV function to failure in PH (measured with stroke volume index as the parameter of RV function); efficiency will be related to MVO2, alterations in substrate metabolism…
The objective in this study is threefold. First, to test the test-retest reproducibility of the 6- minutes walk-run test. Secondly, to test the responsiveness and to compare this with the 6- minutes walk test. Further, to test the construct validity…
The primary hypothesis of our study is that volumetric monitoring will allow for more effective and targeted fluid administration compared to pressure (PAC) monitoring, thereby allowing the attending physician to better optimize fluid infusion…
To investigate the clinical value of OptiVol (TM) impedance measurement by Medtronic(R) InSync Sentry(TM) ICD's. We aim to determine specificity and sensitivity for detecting heart failure. With collected data we want to design a protocol for…