16 results
This study is aimed at determining pharmacokinetics and pharmacodynamics of medications routinely used at the Erasmus Medical Centre in pediatric cardiac surgery during and after cardiopulmonary bypass. The goal is to be able to formulate evidence…
To evaluate the clinical usefulness of the VU-AMS in pediatric cardiology.To validate and improve the measures of stroke volume from the VU-AMS device. VU-AMS stroke volume measures will be compared with stroke volume measured by echocardiography.To…
The objective of the study is to investigate the effect of PEEP ventilation with or without a recruitment maneuver on right ventricular afterload in infants undergoing cardiac surgery.
To investigate whether treatment with candesartan (ARB) reduce 24-hours systolic BP and aortic stiffness more effectively than treatment with metoprolol (beta-blocker) in patients with repaired CoA and late hypertension.
Establish the technical feasibility and safety of implantation of the investigational device, adjustment of the investigational device post-implantation and the ability of the investigational device to reduce mitral valve regurgitation.
The aim of the present study is to evaluate the effect of exercise training on exercise capacity, serum NT-proBNP levels and quality of life in adult patients with a systemic right ventricle.
- To gather long-term data on the safety and tolerability of idebenone inFriedreich*s Ataxia- To explore the effect of idebenone after longer term administration onneurological symptoms and signs as assessed by the InternationalCooperative Ataxia…
To reduce atherosclerotic progression in post-coarctectomy patients.
European registry of children and patients with congenital heart disease that undergo ICD or CRT implantation. This will lead to a larger amount of data leading to increased knowledge about long-term consequences and potential complications.
To determine whether addition of selexipag to current PAH therapy improves exercise capacity, imaging parameters and quality of life, delays time-to-first-PAH-related morbidity and mortality, prevents worsening of World Health Organization…
This study has been transitioned to CTIS with ID 2023-508963-58-00 check the CTIS register for the current data. Primary: To determine the safety and tolerability of CK3773274 in patients with symptomatic HCMSecondary: Assess long-term effects of…
The aim of the study is to obtain sufficient data on beneficial effects of Resveratrol on aortic aneurysm expansion rate and functional properties in patients with Marfan syndrome to justify a phase IIb or a phase III randomized trial.
The study focuses on children and young people with IBD from 6-18 years old. These children have lower levels of physical activity and a limited endurance compared to healthy children. Through this research we want to improve the endurance of…
-To assess autonomic parasympathetic and sympathetic function as well as vascular function in a population of patients with univentricular hearts palliated by the Fontan procedure and compare it with the results in healthy subjects.-To assess the…
Primary:To demonstrate the safety of enalapril Orodispersible Minitablets (ODMTs).Secondary:1. To describe the acceptability and palatability of enalapril ODMTs..2. To collect additional information about pharmacokinetics and pharmacodynamics of…
Primary:To obtain paediatric pharmacokinetic data of enalapril and its active metabolite enalaprilat in patients treated with enalapril ODMTs to describe the dose exposure in the paediatric population with CHD. Secondary:1. To demonstrate safety of…