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Bosentan in Exercise Induced Pulmonary Arterial Hypertension in Congenital Heart Disease

Identify congenital heart disease patients with exercise-induced pulmonary arterial hypertension. Analyze changes in pulmonary arterial pressures at peak exercise in patients with exercise induced pulmonary arterial hypertension before and after…

Right vEntricular Dysfunction in tEtralogy of Fallot: INhibition of the rEnin-angiotensin-aldosterone system*

to improve RV function adult patients with RV dysfunction due to tetralogy of Fallot

Follow-up Safety Trial in children with chronic heart failure therapy receiving Orodispersible Minitablets of Enalapril (WP10 Trial).

Primary:To demonstrate the safety of enalapril Orodispersible Minitablets (ODMTs).Secondary:1. To describe the acceptability and palatability of enalapril ODMTs..2. To collect additional information about pharmacokinetics and pharmacodynamics of…

Orodispersible Minitablets of Enalapril in young children with Heart Failure due to Congenital Heart Disease (WP09 Trial)

Primary:To obtain paediatric pharmacokinetic data of enalapril and its active metabolite enalaprilat in patients treated with enalapril ODMTs to describe the dose exposure in the paediatric population with CHD. Secondary:1. To demonstrate safety of…

Resveratrol as potential aortic growth inhibitor in patients with Marfan Syndrome

The aim of the study is to obtain sufficient data on beneficial effects of Resveratrol on aortic aneurysm expansion rate and functional properties in patients with Marfan syndrome to justify a phase IIb or a phase III randomized trial.

An Open-Label Study of CK-3773274 for Patients with Symptomatic Hypertrophic Cardiomyopathy (HCM).

This study has been transitioned to CTIS with ID 2023-508963-58-00 check the CTIS register for the current data. Primary: To determine the safety and tolerability of CK­3773274 in patients with symptomatic HCMSecondary: Assess long-term effects of…