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Four-dimensional flow cardiac magnetic resonance imaging for the assessment of coarctation of the aorta, a monocenter, prospective, diagnostic cross-sectional study.

1. To investigate non-invasive 4D flow CMR for the assessment of aortic arch stenosis and compare and correlate this to conventional imaging modalities and to three-dimensional rotational angiography (3DRA) with computational fluid dynamics (CFD). 2…

Right ventricle remodeling after pulmonary valve replacement and percutaneous pulmonary valve insertion, a functional and histopathological assessment.

Primary objectives: to investigate functional and histopathological changes of the right ventricle before and after PVR and PPVI. To investigate if non-invasive assessment of RV-remodeling using CMR T1 mapping and T1rho mapping is possible and to…

Pilot study: Evaluation of the non-invasive fetal electrocardiogram, regarding the diagnosis of congenital heart diseases.

Cross-sectional study: To detect the normal range of amplitudes and segment intervals of the fECG. Case-cohort study: To compare the fECG between healthy fetuses and fetuses with various forms of severe CHD. To determine the diagnostic value of fECG…

Pulse oximetry screening for critical congenital heart disease and relevant newborn pathology in the Netherlands

To assess the accuracy and cost-effectiveness of PO screening for CCHD in the Dutch perinatal care system.

Late neonatal neurological outcome in infants with prenatally diagnosed duct dependent CHD and its relation with fetal and neonatal cerebral perfusion

First objective: To assess late neonatal neurological outcome in infants with duct dependent CHD and to gain more insight into the timing of brain damage. We will determine whether the quality of GMs at an age of seven days and three months is…

Pulse oximetry screening for congenital heart disease in community based midwifery care in the Netherlands; a feasibility study

To investigate whether it is feasible to perform a large national implementation study in which community based midwives in the Netherlands use a pulse oximeter for screening newborns for CHD.

4D Flow Quantification with MRI

Primary Objective:• Intracardiac blood total flow and maximum flow velocity measured by 4D MR, and compared with 2D MR.Secondary Objective(s):• Intracardiac pressures as assessed by 4D MR , compared with 2D MR, invasive catheterization and…

Cardiac Performance Index using 'Region Of Interest Tissue Doppler Imaging (ROI-TDI)';
a new parameter for fetal myocardial performance

The primary objective of this study will be to investigate reproducibility of ROI-TDI for fetal cardial performance in a group of normal pregnancies, and compare this new proposed parameter with the Myocardial Performance Index. The data will be…

The Heart And NeuroDevelopment study - Development of the brain in fetuses and children with severe congenital heart disease

To establish benchmark values in healthy control fetuses, to compare these with our cohort of fetuses with severe CHD.

The relationship between depressive symptoms and pro-inflammatory cytokine serum levels in adults with congenital heart disease

The current pilot-study will examine the relation between depressive symptoms and serum levels of pro-inflammatory cytokines in CHD-patients.

The Effect of Exercise Training in Adult Patients with a Systemic Right Ventricle; Three Year Follow-Up

The primary objective of the study is to determine whether exercise training exerts a long term effect on maximal exercise capacity, clinical events, sports participation, serum NT-proBNP and quality of life in adults with a systemic right ventricle…

Atrioventricular septal defect: longterm follow-up after correction

In patients long-term after AVSD correction the objectives are:1) To evaluate myocardial function using novel echocardiographic techniques.2) To study atrial en ventricular size and function in relation to quantification of AVV function with the use…

Spatio-Temporal Image Correlation; the Key to fetal EchocaRdiography
Part I Examination of the cardiac anatomy of the normal fetus.

We will investigate the feasibility of using STIC technology to evaluate the normal fetal cardiac anatomy and morphology in different stages of gestation. Further we aim at making normograms of different intracardiac parameters in relation to…

Spatio-Temporal Image Correlation; the key to fetal EchocaRdiography
Part II congenital heart malformations.

1. To evaluate the clinical usefulness of STIC with post-process rendering capability. Our goal is to investigate whether STIC gives more accurate information about a suspected cardiac anomaly, compared to conventional 2D ultracardiography.2. To…

Standard and novel echocardiographic imaging techniques to assess cardiac dyssynchrony in pediatric patients with cardiac disease

Routine evaluation of dyssynchrony in pediatric patients with cardiac disease is feasible using standard and novel echocardiographic techniques. The extent of cardiac dyssynchrony and its influence on cardiac function differs between groups of…

Functional outcome and quality of life in adult congenital heart disease patients with prosthetic valves*

To investigate the relation between characteristics of valve prosthesis on functional outcome andquality of life in adult patients with CHD. To investigate the prevalence and predictors of PPM in a population withCHD. To investigate the incidence of…

Evaluation of the worlds smallest multiplane Micro Transesophageal Echocardiographic Probe in infants scheduled for Cardiac Surgery for Congenital Heart Disease

In this study we want to evaluate the clinical and diagnostic ability of the micro TEE transducer (7.5 - 5.5 mm diameter tip, 18.5 mm length tip with a 5.2 mm diameter shaft) (Figure 1,2), the smallest multiplane TEE in the world, in pediatric…

Clinical application of real-time three-dimensional echocardiography in pediatric cardiology; Emphasis on left ventricular function

The primary aim of this study is to assess the applicability of RT3DE for the evaluation of left ventricular function in daily clinical practice of a pediatric cardiology service.

Pulmonary atresia with intact ventricular septum: long term follow-up after biventricular vs. univentricular correction

1- To investigate cardiac performance and clinical course after biventricular vs. univentricular repair in PA/IVS. 2- To correlate pre- operative RV and LV function with present RV and LV function. 3- To assess myocardial structural anomalies, which…

Fetal echocardiography using Spatiotemporal Image Correlation (STIC) for the detection of congenital heart malformations (CHD).

1. To investigate whether examination of STIC volumes give an investigator more information about the cardiac anomaly compared to 2D ultrasound.2. To evaluate the reproducibility of fetal heart examinations of STIC volumes by different investigators…