33 results
The primary objective of this study is to assess reasonable safety and performance of the HeartMate PHP to provide hemodynamic support for up to 72 hours in patients with cardiogenic shock requiring stabilization.
The objective of this study is to determine in a randomized fashion the risks as well as the benefits of the addition of vitamin K antagonists to dual anti-platelet therapy in patients with PCI-treated STEMI and LV thrombus formation
The primary study objective is to determine whether Febuxostat daily 80-120 mg is better than Allopurinol daily 100-600 mg in inducing positive changes in Pulse Wave Velocity (PWV) after 36 weeks of treatment.
The primary objective of the study is to evaluate the effect of diuretics on right ventricular function and volume properties in patients with symptomatic right heart failure and PH.
The objective of the study is to obtain information on the bioavailability and pharmacokinetics of the phenolics present in an olive leaf extract (Bonolive®, dose 250 mg), standardized on 40% oleuropein, and to identify the composition of the…
Primary Objective:To determine whether the long*term use of methylphenidate (> 3 years) increases the blood pressure and causes left ventricular hypertrophy (LVH) identified by echocardiography in late adolescent (>=15 years) and young…
The OneShotTM System procedure is designed to provide the anatomical and physiologic benefits of catheter-based RDN at lesser risk to the subject, due to a reduction of complexity of the procedure and design improvements intended to enhance…
The primary efficacy objective of this study is to:* Compare the incidences of the composite endpoints of stroke, systemic embolic event (SEE), myocardial infarction (MI) and cardiovascular (CV) mortality between the edoxaban group and the…
To evaluate the efficacy of MBCT in comparison with treatment as usual (TAU) in women with MCDin terms of: reduction of psychological distress such as anxiety, depression and QOL, reduction of anginal symptoms, and improvement of vascular function
To study dose-dependent hemodynamic and microcirculatory changes during oxygen supply in mechanically ventilated ICU patients.
The study will assess the hypothesis that the combination warfarin & clopidogrel 75 mg/day is superior to triple therapy (warfarin + clopidogrel 75mg/day + aspirin 80mg/day) with respect to bleeding complications while equally safe with…
To investigate if determining dry-weight with the assistance of bioelectrical impedance analysis compared to the current practice will result in a better blood pressure control.
Primary: To evaluate the safety of the study device in patients presenting with severe aortic stenosis (AS) considered to be high risk for surgery.Secondary: To evaluate adverse events and study device performance.
A practical demonstration project in 5 European countries to show that intensive smoking intervention during a preventive cardiovascular risk management programme for patients with cardiovascular (CVD) or other atherosclerotic disease, asymptomatic…
Comparison of adenosine infusion and bolus injection of regadenoson for induction of maximum coronary hyperemia.
Primary:To assess after administration of a single oral dose of 75 mg S 38844 containing 55 *Ci (2.035 MBq) of [14C]-S 38844:* The excretion balance of total radioactivity;* The pharmacokinetics of total radioactivity in blood and plasma;* The…
In preparation for a large multi-center trial on the efficacy and safety of SENS for chronic intractable angina pectoris, we want to conduct a pilot, explorative trial to assess the feasibility, safety and efficacy of SENS implantation in this…
The objective of the study is to evaluate whether esophagal lesions are created by cryo-ballon technique for AF ablation, and to compare this with a group of patients undergoing radiofrequency catheter ablation of AF.
The primary aim of the ISCHEMIA trial is to determine whether an invasive strategy of routine early catheterization followed by optimal revascularization, in addition to OMT, will reduce the primary composite endpoint of cardiovascular death or…
Obtain information on the spatial movement and deflection of implanted leads by capturing three cardiac cycles with a simultaneous biplane cinefluoroscopy imaging system. The lead movement and deflection data will be used to evaluate the lead strain…