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Finding the optimal treatment of severe panic symptoms in patients presenting at the emergency department with non-cardiac chest pain or palpitations. A cognitive behavioural therapy based intervention versus an information sheet. A randomized controlled trial.

The objective of our study is to examine the effectiveness of a cognitive behavioural therapy based intervention compared to an information leaflet on anxiety symptoms after one month, in patients presenting at the emergency unit with non-cardiac…

Helium induced organ protection and the role of circulatory factors:
secretion of Caveolin to the bloodstream (HeCav) in humans.

The primary objective of this study is to investigate whether serum taken from volunteers subjected to 30 minutes of helium inhalation can protect different cell types against hypoxia-reperfusion induced damage and to investigate the role of…

The effects of capsaicin and tea on sodium and water homeostasis as measured by osmoregulation and blood pressure.

1. To assess whether acute TRPV1 activation by capsaicin or ENaC down regulation by flavonoids modulate osmoregulation in healthy subjects2. To assess whether capsaicin and flavonoids affect blood pressure

The (cost-) effectiveness of a lifestyle intervention for male workers at risk for cardiovascular disease in the construction industry in The Netherlands.

The main objective of the study is to evaluate the effectiveness of an individually- based lifestyle intervention for male workers with an elevated CVD risk in the construction industry in The Netherlands.

The Goal dIrected perFusion Trial, a multi-center, prospective, randomized, controlled study.

The present study is designed to verify the hypothesis that a strategy based on a goal-directed perfusion, aimed to avoid a nadir DO2 below the critical threshold, is effective in limiting the postoperative AKI rate.

A Randomized, Single-blind, Propofol-controlled Phase III Study Evaluating the Efficacy and Safety of Remimazolam in General Anesthesia in Adult Patients Undergoing Cardiac Surgery, including Follow-up Sedation in the Post-anesthesia Care Unit / Intensive Care Unit

The objectives are:* to show non-inferiority of remimazolam compared with propofol in terms of successful maintenance of sedation defined as a Narcotrend index of 60 or less during at least 85% of the maintenance time without the use of rescue…

Intervention study investigating the effect of a dietary intervention geared towards improved adherence to the Dutch dietary guidelines on the 10-year risk for recurrent vascular events (SMART risk score) in patients with cardiovascular diseases compared with usual care.

The aim of this study is to investigate the effect of a dietary intervention geared towards improved adherence to the Dutch dietary guidelines on the 10-year risk for recurrent vascular events (SMART risk score) in patients with cardiovascular…

Cardiac Care Bridge

The aim of this study is to examine the effectiveness of a nurse-coordinated Cardiac Care Bridge program consisting of care coordination, cardiovascular risk management and home-based rehabilitation for high-risk cardiac patients of 70 years and…