25 results
To evaluate the efficacy of 250ml 1.4% sodium bicarbonate versus hypotone saline hydration prior to TAVI in patients with CKD to prevent CIN.
The purpose of this registry is to expand upon existing data sets, to identify patient characteristics and indicators related to complications and clinical benefits for patients with symptomatic severe calcific degenerative aortic stenosis that are…
The Claret device (Claret Inc.) is an Embolic Protection Device (EPD) consisting of two nitinol baskets to be introduced through the right radial artery. One basket is positioned in the brachiocephalic trunk, the other in the left common carotid…
To demonstrate the safety and performance of the Embolic Deflection Device (TriGuard*HDH) in patients undergoing Transcatheter Aortic Valve Replacement (TAVI).
To assess the safety, efficacy, and performance of the TriGuard HDH embolic deflection device in patients undergoing transcatheter aortic valve implantation (TAVI), in comparison with patients undergoing unprotected TAVI.
The primary objective of this study is to identify mutations associated with the development of a bicuspid aortic valve. To this end the study will focus on genes important for aortic valve formation. As an extension of the primary objective, a…
Detection of High Intensity Transient Signals as hemodynamic parameter in patients undergoing aortic valve replacement
The purpose of this study is to answer the following question: Leads a primary coagulation corrected with a single dose of fibrinogen concentrate after ascending aorta-arc reconstruction to a decrease in the number of allogenic blood transfusions,…
The purpose of this study (APPIRED III) is to investigate the efficacy of administered prophylactically RESCAP with regard to the prevention of (severe) renal failure, or renal dysfunction, reducing morbidity and mortality. It also looks at systemic…
The objective of this study is to demonstrate that use of the Sentinel® Cerebral Protection System significantly reduces the risk of periproceduralstroke (*72 hours) after transcatheter aortic valve replacement (TAVR).
Primary Objective:1) Assess different LV loading mechanisms in Barlow's Disease (BD) versus Fibroelastic deficiency (FED), including transvalvular mitral regurgitant and prolapse volume, both with echocardiography and cardiac magnetic resonance…
To investigate whether treatment with edoxaban leads to a decrease in incidence of leaflet thickening and is clinical efficient and safe.
To test the hypothesis that patients with AoS have a higher prevalence of CHIP driving mutations compared to control subjects. Secondary objectives are to perform extensive phenotyping of circulating monocytes.
To evaluate the efficacy and safety of peri-procedurally continued versus interrupted oral anticoagulants in patients undergoing transcatheter aortic valve implantation.
Assess BMP10 secretion in patients with pulmonary arterial hypertension and its effect on right ventricular adaptation to pressure overload.
The goal of this study is to determine if MDMA use is associated with a relevant risk of toxic valvulopathy. The popularity of the drug is attributed to its assumed low-risk profile, but these assumptions could be incorrect due to underreporting of…
Main objectives of the study can be summarized as follows:1. To thoroughly characterize valve tissue of Barlow*s MR as compared to FED. 2. To investigate the familial distribution of different forms of organic MR and the prevalence of genetic…
Primary objectives: 1. To assess the difference in bioprosthetic leaflet 18F-NaF PET activity, as an early marker of transcatheter valve degeneration, between patients with vs. without SCLT at five years after TAVI.2. To assess the difference in…
This study has been transitioned to CTIS with ID 2024-513486-39-00 check the CTIS register for the current data. The main objective of this study is to determine the effect of colchicine on the progression of moderate AS in asymptomatic patients.
Evaluate whether patients with elevated Lp(a) are characterized by increased active calcification of the aortic valve.