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Genes and gene-function in bicuspid aortic valves

The primary objective of this study is to identify mutations associated with the development of a bicuspid aortic valve. To this end the study will focus on genes important for aortic valve formation. As an extension of the primary objective, a…

Detection of High Intensity Transient Signals after aortic valve replacement

Detection of High Intensity Transient Signals as hemodynamic parameter in patients undergoing aortic valve replacement

Mechanistic insights in mitral valve prolapse and associated left ventricular remodelling: Barlow*s Disease versus Fibroelastic Deficiency

Primary Objective:1) Assess different LV loading mechanisms in Barlow's Disease (BD) versus Fibroelastic deficiency (FED), including transvalvular mitral regurgitant and prolapse volume, both with echocardiography and cardiac magnetic resonance…

Myeloid cell reprogramming in aortic valve stenosis

To test the hypothesis that patients with AoS have a higher prevalence of CHIP driving mutations compared to control subjects. Secondary objectives are to perform extensive phenotyping of circulating monocytes.

Pulmonary artERial hypertenSion: bonE morPHOgeNEtic protein signaling out of control (PERSEPHONE)

Assess BMP10 secretion in patients with pulmonary arterial hypertension and its effect on right ventricular adaptation to pressure overload.

Is the recreational use of MDMA related to the prevalence of toxic cardiac valvulopathy? A cross sectional study between non-, incidental and heavy MDMA users.

The goal of this study is to determine if MDMA use is associated with a relevant risk of toxic valvulopathy. The popularity of the drug is attributed to its assumed low-risk profile, but these assumptions could be incorrect due to underreporting of…

Organic mitral regurgitation (MR): genetic analysis, morphological and tissue characterization.

Main objectives of the study can be summarized as follows:1. To thoroughly characterize valve tissue of Barlow*s MR as compared to FED. 2. To investigate the familial distribution of different forms of organic MR and the prevalence of genetic…

The Effect of Subclinical Leaflet Thrombosis and Prosthesis Type on Transcatheter Aortic Valve Degeneration

Primary objectives: 1. To assess the difference in bioprosthetic leaflet 18F-NaF PET activity, as an early marker of transcatheter valve degeneration, between patients with vs. without SCLT at five years after TAVI.2. To assess the difference in…

Does colchicine reduce progression of aortic valve stenosis?

This study has been transitioned to CTIS with ID 2024-513486-39-00 check the CTIS register for the current data. The main objective of this study is to determine the effect of colchicine on the progression of moderate AS in asymptomatic patients.

Establishing elevated lipoprotein(a) as a target in calcific aortic valve disease

Evaluate whether patients with elevated Lp(a) are characterized by increased active calcification of the aortic valve.

DIagnostic and prognostic value of intracoronary physiologic indices and need for revascularisation in severe aortic VAlve disease (DIVA)

This study is designed to assess diagnostic and prognostic value of intracoronary flow- and pressure measurements in patients with severe aortic valve stenosis and concomitant coronary artery disease, unravelling the physiological impact on coronary…

ATTR amyloidosis in patients undergoing transcatheter aortic valve replacement: from prevalence to hemodynamic consequence.

Objective: 1. Investigate the prevalence of ATTR in patients undergoing TAVR in the Netherlands.2. To determine whether ATTR influences the effectiveness of TAVR treatment on LV dysfunction.

Risk factors for progression of aortic valve stenosis

- To document the average progression of AVS in a large population of patients with mild to moderate AVS.- To assess the prevalence of elevated Lp(a) among patients with mild to moderate AVS.- To identify lipid and genetic risk factors for AVS.

Endothelial Colony Forming Cells, Endothelial Progenitor Cells and Bicuspid Aortic Valves: in vitro culture of peripheral blood cells to study biomarkers and pathogenesis in BAV?

The main objective of this study is to find biomarkers for the prognosis of the BAV patients by investigating ECFC and EPC functioning, and to gain knowledge on physiological and pathological processes in patients by investigating molecular…