386 results
The primary objective is to examine the impact of t-LLVS on electrophysiological properties of the atria and ventricles. Secondary objectives are:- to elucidate the correlation between proteostasis marker levels in serum and atrial tissue, and the…
Primary objective:To evaluate the clinical efficacy and side effects (adverse events) of a single dose stereotactic radiotherapy on the electro-anatomical arrhythmia substrate, inaccessible by the current state of the art catheter ablation…
This pilot study sets out to assess stimulation-evoked PESP-BP using various stimulation protocols and to compare outcomes with PESP-BP by spontaneous ESB. Moreover, we aim to derive a stimulation protocol for PESP-BP assessment, which can be used…
To quantify the role of different abnormal loading conditions on atrial and ventricular electropathology in paediatric patients with CHD.
To study whether epigenetic profiles of study participants who suffered an out-of-hospital cardiac arrest (OHCA) that were collected immediately after OHCA (in ARREST biobank) are similar their epigenetic profiles collected at least 9 months after…
The objective of the study is to confirm the long-term safety of the Tendril STS and Isoflex leads, implanted with the Assurity MRI* or Endurity MRI* pacemakers, in patients undergoing clinically indicated 3T MRI scans.
To test the effect and incidence of hypoxemia when oxygen supplementation through HFNC as compared to LFNC in patients with atrial fibrillation undergoing point-by-point ablation (like RFCA or Galaxy PFA) and deep sedation.
To identify predictors of success of AF ablation including clinical factors, AF recurrence patterns, anatomical and electrophysiological characteristics, circulating biomarkers and individual genetic background.
The main goals of this study are to study the effects of VHPSD ablation on the duration of a pulmonary vein isolation procedure, and on transient (edema) and persistent (fibrosis) effects of VHPSD ablation in the left atrial wall.
Study the effectiveness and safety of LAAO in non-valvular AF patients at high stroke risk unable to use OAC
The VOLT AF First-in-Human (FIH) study will collect feasibility data to show that the Volt PFA System functions as intended in a clinical setting and to demonstrate acute safety and effectiveness for the treatment of symptomatic, recurrent…
The purpose of the study is to provide ongoing post-market demonstration of the safety and performance of the FARAPULSEPulsed Field Ablation System in the treatment of patients with paroxysmal atrial fibrillation (PAF).
This prospective, randomized, controlled, unblinded, multicenter study aims at comparing procedural time between conventional CLOSE-guided PVI (35W/50W) versus very high power radiofrequency delivery (90W) in AF patients scheduled for a first PVI.
The objective of this study is to evaluate the reliability of the Ablacon Electrographic Flow (EGF) algorithm technology (Ablamap® Software) to identify AF sources and guide ablation therapy in patients with persistent atrial fibrillation.
Study endpoints: This study will capture the following endpoints: 1. To determine if use of IIa antagonist(Dabigatran) is associated with increased platelet activation as compared to Xa(Apixaban, edoxaban, rivaroxaban) 2. To determine if use of IIa…
Primary objective: Our primary objective is to investigate whether niagen normalizes blood-based energy metabolites, mitochondrial levels and proteostasis levels. Secondary objective: To examine whether niagen reduces AF burden in patients with…
Main objectiveTo identify and describe the electrophysiological substrate and triggers in patients with (an increased risk of) VTAs using ECGI, in order to improve understanding of arrhythmic mechanisms and use these for arrhythmia risk…
The primary objective is to evaluate the antral lesion size using ultrahighdensity (UHDx) mapping pre- and post-cryoablation with the 31 mm balloon size CB. Secondary objectives are the proportion of pulmonary veins (PVs) where a 31 mm CB could be…
Protocol page 33:The purpose of the study is to provide data demonstrating the safety and effectiveness of the PFAsystem for the treatment of atrial fibrillation. The study will also provide first in human insights intoclinical safety and device…
RED-LRGP: To investigate the yield of a screen-like early diagnosis strategy as compared to usual primary care in terms of the number of newly diagnosed coronary artery disease, atrial fibrillation, and heart failure in community people aged 50-80…